RT Journal Article
T1 Gastrointestinal Tracking and Gastric Emptying of Coated Capsules in Rats with or without Sedation Using CT imaging
A1 Gómez Lado, Noemí
A1 Seoane Viaño, Iria
A1 Matiz, Silvia
A1 Madla, Christine M.
A1 Yadav, Vipul
A1 Aguiar Fernández, Pablo
A1 Basit, Abdul W.
A1 Goyanes Goyanes, Álvaro
K1 Medical Imaging
K1 Computed Tomography
K1 Anesthesia
K1 Capsule Size
K1 Gastric Emptying
K1 Rodents
K1 Gastrointestinal Tract
K1 Oral Drug Delivery
K1 Drug Absorption
AB Following oral administration, gastric emptying is often a rate-limiting step in the absorption of drugs and is dependent on both physiological and pharmaceutical factors. To guide translation into humans, small animal imaging during pre-clinical studies has been increasingly used to localise the gastrointestinal transit of solid dosage forms. In contrast to humans, however, anaesthesia is usually required for effective imaging in animals which may have unintended effects on intestinal physiology. This study evaluated the effect of anaesthesia and capsule size on the gastric emptying rate of coated capsules in rats. Computed tomography (CT) imaging was used to track and locate the capsules through the gastrointestinal tract. Two commercial gelatine mini-capsules (size 9 and 9h) were filled with barium sulphate (contrast agent) and coated using Eudragit L. Under the effect of anaesthesia, none of the capsules emptied from the stomach. In non-anaesthetised rats, most of the size 9 capsules did not empty from the stomach, whereas the majority of the smaller size 9h capsules successfully emptied from the stomach and moved into the intestine. This study demonstrates that even with capsules designed to empty from the stomach in rats, the gastric emptying of such solid oral dosage forms is not guaranteed. In addition, the use of anaesthesia was found to abolish gastric emptying of both capsule sizes. The work herein further highlights the utility of CT imaging for the effective visualisation and location of solid dosage forms in the intestinal tract of rats without the use of anaesthesia.
PB MDPI
YR 2020
FD 2020
LK http://hdl.handle.net/10347/21924
UL http://hdl.handle.net/10347/21924
LA eng
NO Gómez-Lado, N.; Seoane-Viaño, I.; Matiz, S.; Madla, C.M.; Yadav, V.; Aguiar, P.; Basit, A.W.; Goyanes, A. Gastrointestinal Tracking and Gastric Emptying of Coated Capsules in Rats with or without Sedation Using CT imaging. Pharmaceutics 2020, 12, 81.
NO This research was funded by the Engineering and Physical Sciences Research Council (EPSRC) UK, grant number EP/L01646X
DS Minerva
RD 24 abr 2026