RT Journal Article
T1 Validation of the Spanish version of the cerebellar cognitive-affective syndrome scale
A1 Serrano Munuera, Carmen
A1 Martínez Regueiro, Rocío
A1 Martínez Fernández, Eva María
A1 Alemany Perna, Berta
A1 López Domínguez, Daniel
A1 Rojas Bartolomé, Laura
A1 Adarmes Gómez, Astrid
A1 Pérez Torre, Paula
A1 Abenza Abildúia. María Jesús, 
A1 Rouco Axpe, Idoia
A1 Feria Villar, Inmaculada
A1 Pérez Pérez, Jesús
A1 Schmahmann, Jeremy D.
A1 García-Sánchez, Carmen
K1 ataxia
K1 cerebellum
K1 CCAS
K1 cognitive screening
K1 rating scale
K1 Schmahmann scale
AB Objective: To validate the Spanish version of the Cerebellar Cognitive-Affective Syndrome scale (CCAS-S), originally published in 2018, in patients with cerebellar ataxia and healthy subjects, as an adapted Spanish version based on normative data has not yet been published or validated. Methods: Spanish CCAS-S was ­administered prospectively to 158 patients with cerebellar ataxia and 164 matched healthy subjects from ­different regions of Spain. Discriminant validity and reliability were evaluated. A subgroup of 30 patients underwent detailed neuropsychological examinations to confirm the construct validity. The Scale for the Assessment and Rating of Ataxia (SARA) and the Brief Ataxia Rating Scale (BARS) were used to assess motor performance. Results: This Spanish instrument demonstrates reliability and exhibits statistically significant differences in performance between patients and healthy subjects. Our analysis revealed lower values for specificity in detecting possible, probable, or definite CCAS compared to those reported in the US validation study when utilizing the original cutoff values. Upon application of the appropriate ­correction factor for education, the specificity values approximated those reported for probable and definite CCAS diagnostics in the original investigation. Conclusions: The adapted Spanish CCAS-S has demonstrated validity and good reliability in this cohort. Discriminant validity was satisfactory for probable and definite CCAS when the correction for education was applied, and modified template and instructions have been developed. Further research is necessary to investigate the significance of the possible CCAS category, as diagnosed using the Spanish version, as well as to assess the performance of the corrected scale in other Spanish-speaking countries.
PB Taylor & Francis
SN 1385-4046
YR 2025
FD 2025-04-22
LK https://hdl.handle.net/10347/46029
UL https://hdl.handle.net/10347/46029
LA eng
NO Serrano-Munuera, C., Martínez-Regueiro, R., Martínez Fernández, E. M., Alemany Perna, B., López Domínguez, D., Rojas-Bartolomé, L., … García-Sánchez, C. (2026). Validation of the Spanish version of the cerebellar cognitive-affective syndrome scale. The Clinical Neuropsychologist, 40(1), 289–305. https://doi.org/10.1080/13854046.2025.2488453
DS Minerva
RD 24 abr 2026