RT Journal Article
T1 Bacteremia in Children Hospitalized with Respiratory Syncytial Virus Infection
A1 Cebey López, Miriam
A1 Pardo Seco, Jacobo José
A1 Gómez Carballa, Alberto
A1 Martinón Torres, Nazareth
A1 Martinón Sánchez, José María
A1 Justicia Grande, Antonio
A1 Rivero Calle, Irene
A1 Pinnock, Ellie
A1 Salas Ellacuriaga, Antonio
A1 Fink, Colin
A1 Martinón Torres, Federico
A1 GENDRES network, 
AB BackgroundThe risk of bacteremia is considered low in children with acute bronchiolitis. However the rate of occult bacteremia in infants with RSV infection is not well established. The aim was to determine the actual rate and predictive factors of bacteremia in children admitted to hospital due to confirmed RSV acute respiratory illness (ARI), using both conventional culture and molecular techniques.MethodsA prospective multicenter study (GENDRES-network) was conducted between 2011–2013 in children under the age of two admitted to hospital because of an ARI. Among those RSV-positive, bacterial presence in blood was assessed using PCR for Meningococcus, Streptococcus pneumoniae, Haemophilus influenzae, Streptococcus pyogenes, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus aureus, in addition to conventional cultures.Results66 children with positive RSV respiratory illness were included. In 10.6% patients, bacterial presence was detected: H. influenzae (n = 4) and S. pneumoniae (n = 2). In those patients with bacteremia, there was a previous suspicion of bacterial superinfection and had received empirical antibiotic treatment 6 out of 7 (85.7%) patients. There were significant differences in terms of severity between children with positive bacterial PCR and those with negative results: PICU admission (100% vs. 50%, P-value = 0.015); respiratory support necessity (100% vs. 18.6%, P-value < 0.001); Wood-Downes score (mean = 8.7 vs. 4.8 points, P-value < 0.001); GENVIP scale (mean = 17 vs. 10.1, P-value < 0.001); and length of hospitalization (mean = 12.1 vs. 7.5 days, P-value = 0.007).ConclusionBacteremia is not frequent in infants hospitalized with RSV respiratory infection, however, it should be considered in the most severe cases
PB PLOS
YR 2016
FD 2016-02-12
LK http://hdl.handle.net/10347/15914
UL http://hdl.handle.net/10347/15914
LA eng
NO Cebey-López M, Pardo-Seco J, Gómez-Carballa A, Martinón-Torres N, Martinón-Sánchez JM, Justicia-Grande A, et al. (2016) Bacteremia in Children Hospitalized with Respiratory Syncytial Virus Infection. PLoS ONE 11(2): e0146599. https://doi.org/10.1371/journal.pone.0146599
NO This work was supported by the Spanish Government (Research Program Health Research Fund (FIS; PI10/00540 y PI13/02382) National Plan I + D + I and FEDER funds) and Regional Galician funds (Promotion of Research Project 10 PXIB 918 184 PR) (FMT), and Ministerio de Ciencia e Innovación (SAF2011-26983) and the Plan Galego IDT, Xunta de Galicia (EM 2012/045) (AS). MC’s research activities had been supported by grants from Instituto de Investigación Sanitaria de Santiago de Compostela. FMT’s research activities have been supported by grants from Instituto Carlos III (Intensificación de la actividad investigadora). Investigators received funding from the European Union’s Seventh Framework Program under ECGA no. 279185 (EUCLIDS) during the production of this paper
DS Minerva
RD 27 abr 2026