RT Journal Article
T1 Recruitment of RNA molecules by connexin RNA-binding motifs: Implication in RNA and DNA transport through microvesicles and exosomes
A1 Varela-Eirin, Marta
A1 Varela Vázquez, Adrián
A1 Rodríguez-Candela Mateos, Marina
A1 Vila-Sanjurjo, Anton
A1 Fonseca, Eduardo
A1 Mascareñas Cid, José Luis
A1 Vázquez Sentís, Marco Eugenio
A1 Mayán, María D.
K1 Connexin43
K1 Connexin26
K1 Cellular communication
K1 Microvesicles
K1 Exosomes
K1 RNA-binding domains
AB Connexins (Cxs) are integral membrane proteins that form high-conductance plasma membrane channels, allowing communication from cell to cell (via gap junctions) and from cells to the extracellular environment (via hemichannels). Initially described for their role in joining excitable cells (nerve and muscle), gap junctions (GJs) are found between virtually all cells in solid tissues and are essential for functional coordination by enabling the direct transfer of small signalling molecules, metabolites, ions, and electrical signals from cell to cell. Several studies have revealed diverse channel-independent functions of Cxs, which include the control of cell growth and tumourigenicity. Connexin43 (Cx43) is the most widespread Cx in the human body. The myriad roles of Cx43 and its implication in the development of disorders such as cancer, inflammation, osteoarthritis and Alzheimer's disease have given rise to many novel questions. Several RNA- and DNA-binding motifs were predicted in the Cx43 and Cx26 sequences using different computational methods. This review provides insights into new, ground-breaking functions of Cxs, highlighting important areas for future work such as transfer of genetic information through extracellular vesicles. We discuss the implication of potential RNA- and DNA-binding domains in the Cx43 and Cx26 sequences in the cellular communication and control of signalling pathways
PB Elsevier
SN 0167-4889
YR 2017
FD 2017-04
LK http://hdl.handle.net/10347/17407
UL http://hdl.handle.net/10347/17407
LA eng
NO Varela-Eirin, M., Varela-Vazquez, A., Rodríguez-Candela Mateos, M., Vila-Sanjurjo, A., Fonseca, E., & Mascareñas, J. et al. (2017). Recruitment of RNA molecules by connexin RNA-binding motifs: Implication in RNA and DNA transport through microvesicles and exosomes. Biochimica Et Biophysica Acta (BBA) - Molecular Cell Research, 1864(4), 728-736. doi: 10.1016/j.bbamcr.2017.02.001
NO This work was supported in part through funding from the Society for Research on Bone and Mineral Metabolism - Grant number FEIOMM2016 (to M.D.M.), by grant PRECIPITA-2015-000139 from the FECYT-Ministry of Economy and Competitiveness (to M.D.M), by grants PI13/00591 and PI16/00035 from the Health Institute “Carlos III” (ISCIII, Spain) and co-financed by the European Regional Development Fund, “A way of making Europe” from the European Union (to M.D.M.), by a grant from Xunta de Galicia (pre-doctoral fellowship) to M.V.-E., and by a grant from the Ministry of Education, Culture and Sports, Spain (FPU grant to M.R.-C.M.)
DS Minerva
RD 30 abr 2026