RT Dissertation/Thesis
T1 Iridium-Catalyzed Enantioselective Hydrofunctionalization of Allenes
A1 Rey López, Alejandro
K1 Iridium
K1 allenes
K1 enantioselective
K1 hydrofunctionalization
K1 quaternary stereocenters
AB Since the earliest days, humans have relied on natural products for medicines and materials, but their limitations drove the development of synthetic methodologies to access complex molecules with improved properties. The advent of transition metal catalysis revolutionized bond formation under mild and sustainable conditions, while asymmetric catalysis enabled the enantioselective construction of challenging tertiary and quaternary stereocenters. This thesis focuses on developing transition metal catalyzed C-H and N-H bond additions across allenes to create complex chiral molecules. In Section I, an intramolecular Iridium(I) catalyzed exo-hydroarylation of allenyl-tethered pyrroles and indoles afforded polycyclic products with quaternary centers, enabling a concise formal synthesis of Rhazinilam.
YR 2026
FD 2026
LK https://hdl.handle.net/10347/46459
UL https://hdl.handle.net/10347/46459
LA eng
DS Minerva
RD 21 abr 2026