RT Journal Article
T1 Rapid method for quantification of nine sulfonamides in bovine milk using HPLC/MS/MS and without using SPE
A1 Nebot García, Carolina
A1 Regal López, Patricia
A1 Miranda López, José Manuel
A1 Fente Sampayo, Cristina Asunción
A1 Cepeda Sáez, Alberto
K1 Sulfonamides
K1 Milk
K1 High-performance liquid chromatography
K1 Mass spectrometry
AB Sulfonamides are antimicrobial agents widely employed in animal production and their residues in food could be an important risk to human health. In the dairy industry, large quantities of milk are monitored daily for the presence of sulfonamides. A simple and low-cost extraction protocol followed by a liquid chromatographic–tandem mass spectrometry method was developed for the simultaneous detection of nine sulfonamides in whole milk. The method was validated at the maximum residue limits established by European legislation. The limits of quantification obtained for most sulfonamides were between 12.5 and 25 μg kg−1, detection capabilities ranged from 116 to 145 μg kg−1, and recoveries, at 100 μg kg−1, were greater than 89 ± 12.5%. The method was employed to analyse 100 raw whole bovine milk samples collected from dairy farms in the northwest region of Spain. All of the samples were found to be compliant, but two were positive; one for sulfadiazine and the other for sulfamethoxipyridazine.
PB Elsevier
SN 0308-8146
YR 2013
FD 2013-12-01
LK https://hdl.handle.net/10347/45563
UL https://hdl.handle.net/10347/45563
LA eng
NO Carolina Nebot, Patricia Regal, Jose Manuel Miranda, Cristina Fente, Alberto Cepeda, Rapid method for quantification of nine sulfonamides in bovine milk using HPLC/MS/MS and without using SPE, Food Chemistry, Volume 141, Issue 3, 2013, Pages 2294-2299, ISSN 0308-8146, https://doi.org/10.1016/j.foodchem.2013.04.099.
DS Minerva
RD 28 abr 2026