RT Journal Article
T1 Capability of the inter-eye differences in osmolarity, break-up time and corneal staining on the diagnostic of dry eye
A1 Pena Verdeal, Hugo
A1 García Queiruga, Jacobo
A1 Sabucedo Villamarín, Belén
A1 Giráldez Fernández, María Jesús
A1 García Resúa, Carlos
A1 Yebra-Pimentel Vilar, Eva
K1 Dry Eye Syndromes
K1 Tear Film Osmolarity
K1 Fluorescein Break-Up Time
K1 Ocular Surface Staining
K1 ROC Curve
AB Purpose: Inter-eye variability is a recognized characteristic of Dry Eye Disease (DED) and has been proposed as a diagnostic indicator in clinical practice. This study aimed to assess the diagnostic potential of the absolute difference between eyes in three key diagnostic tests recommended by the Tear Film and Ocular Surface Society Dry Eye Workshop II (TFOS DEWS II) Diagnostic Methodology report: tear film osmolarity, Fluorescein Break-Up Time (FBUT), and ocular surface staining.Methods: A total of 180 participants were included in a cross-sectional study. Before a dry eye examination, participants completed an online self-administered OSDI questionnaire. The TFOS DEWS II diagnostic criteria for DED assessment were used: along with OSDI, osmolarity, FBUT and ocular surface staining were measured in all participants in both eyes following standardized methodology. Based on signs and symptoms, participants were diagnosed as having No DED or DED. After diagnosis, parameters were computed as the right and left eyes' absolute inter-eye difference (|OD-OS|). Results: Receiver Operating Characteristics analyses for computed parameters were used based on the previous diagnosis. ROC analyses showed that Osmolarity|OD-OS| have a diagnostic capability to differentiate between No DED and DED participants with a cut-off value of 9.5 mOsm/L (AUC = 0.745 ± 0.052, p < 0.003), whereas FBUT|OD-OS| and Corneal Stainning|OD-OS| have not (AUC, both p ≥ 0.160).Conclusion: The present study found that the Osmolarity|OD-OS| parameter could be used as a diagnostic indicator for DED assessment, while the FBUT|OD-OS| and the Corneal Staining|OD-OS| parameters do not have this capability.
PB Taylor and Francis
YR 2023
FD 2023
LK http://hdl.handle.net/10347/33548
UL http://hdl.handle.net/10347/33548
LA eng
NO Pena-Verdeal, H., Garcia-Queiruga, J., Sabucedo-Villamarin, B., Giraldez, M. J., García-Resúa, C., & Yebra-Pimentel, E. (2023). Capability of the Inter-Eye Differences in Osmolarity, Break-Up Time and Corneal Staining on the Diagnostic of Dry Eye. Ocular Immunology and Inflammation, 1–8
NO This is an Accepted Manuscript of an article published by Taylor & Francis in Ocular Immunology and Inflammation on 5 Dec 2023, available at: https://doi.org/10.1080/09273948.2023.2285449
DS Minerva
RD 23 abr 2026