RT Journal Article
T1 The neuroprotective effects of astaxanthin: therapeutic targets and clinical perspective
A1 Fakhri, Sajad
A1 Yosifova Aneva, Ina
A1 Farzaei, Mohammad Hosein
A1 Sobarzo Sánchez, Eduardo Marcelo
K1 Neurodegenerative diseases
K1 Astaxanthin
K1 Pharmacology
K1 Neuroprotective agent
K1 Oxidative stress
K1 Neuroinflammation
K1 Apoptosis
K1 Drug delivery system
AB As the leading causes of human disability and mortality, neurological diseases affectmillions of people worldwide and are on the rise. Although the general roles of several signalingpathways in the pathogenesis of neurodegenerative disorders have so far been identified, the exactpathophysiology of neuronal disorders and their effective treatments have not yet been preciselyelucidated. This requires multi-target treatments, which should simultaneously attenuate neuronalinflammation, oxidative stress, and apoptosis. In this regard, astaxanthin (AST) has gained growinginterest as a multi-target pharmacological agent against neurological disorders including Parkinson’sdisease (PD), Alzheimer’s disease (AD), brain and spinal cord injuries, neuropathic pain (NP),aging, depression, and autism. The present review highlights the neuroprotective effects of ASTmainly based on its anti-inflammatory, antioxidative, and anti-apoptotic properties that underlies itspharmacological mechanisms of action to tackle neurodegeneration. The need to develop novel ASTdelivery systems, including nanoformulations, targeted therapy, and beyond, is also considered
PB MDPI
YR 2019
FD 2019
LK http://hdl.handle.net/10347/22470
UL http://hdl.handle.net/10347/22470
LA eng
NO Fakhri, S., Yosifova Aneva, I., Farzaei, M.H., Sobarzo-Sánchez, E. (2019). The neuroprotective effects of astaxanthin: therapeutic targets and clinical perspective. Molecules 24(14), 2640; doi: 10.3390/molecules24142640
DS Minerva
RD 24 abr 2026