RT Journal Article
T1 Dopamine regulates adult neurogenesis in the ventricular-subventricular zone via dopamine D3 angiotensin type 2 receptor interactions
A1 García Garrote, María
A1 Parga Martín, Juan Andrés
A1 Labandeira Guerra, Pablo José
A1 Labandeira García, José Luis
A1 Rodríguez Pallares, Jannette
K1 Angiotensin
K1 Dopamine receptors
K1 Dopaminergic grafts
K1 Neural stem cells
K1 Parkinson's disease
K1 Subependymal zone
AB Adult neurogenesis is a dynamic and highly regulated process, and different studies suggest that dopamine modulates ventricular-subventricular zone (V-SVZ) neurogenesis. However, the specific role of dopamine and the mechanisms/factors underlying its effects on physiological and pathological conditions such as Parkinson's disease (PD) are not fully understood. Recent studies have described counter-regulatory interactions between renin-angiotensin system (RAS) and dopamine in peripheral tissues and in the nigrostriatal system. We have previously demonstrated that angiotensin receptors regulate proliferation and generation of neuroblasts in the rodent V-SVZ. However, possible interactions between dopamine receptors and RAS in the V-SVZ and their role in alterations of neurogenesis in animal models of PD have not been investigated. In V-SVZ cultures, activation of dopamine receptors induced changes in the expression of angiotensin receptors. Moreover, dopamine, via D2-like receptors and particularly D3 receptors, increased generation of neurospheres derived from the V-SVZ and this effect was mediated by angiotensin type-2 (AT2) receptors. In rats, we observed a marked reduction in proliferation and generation of neuroblasts in the V-SVZ of dopamine-depleted animals, and inhibition of AT1 receptors or activation of AT2 receptors restored proliferation and generation of neuroblasts to control levels. Moreover, intrastriatal mesencephalic grafts partially restored proliferation and generation of neuroblasts observed in the V-SVZ of dopamine-depleted rats. Our data revealed that dopamine and angiotensin receptor interactions play a major role in the regulation of V-SVZ and suggest potential beneficial effects of RAS modulators on the regulation of adult V-SVZ neurogenesis
PB Wiley
SN 1066-5099
YR 2021
FD 2021
LK http://hdl.handle.net/10347/29117
UL http://hdl.handle.net/10347/29117
LA eng
NO Stem Cells. 2021;39:1778–1794. https://doi.org/10.1002/stem.3457
NO This work was supported by grants from Instituto de Salud Carlos III (RD16/011/0016), Secretaría de Estado de Investigación, Desarrollo e Innovación (Grant/Award, number RTI2018-098830-B-I00), Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia (ED431G/05, ED431C 2018/10), and European Regional Development Fund (FEDER)
DS Minerva
RD 4 may 2026