RT Journal Article
T1 Adult Sox2+ stem cell exhaustion in mice results in cellular senescence and premature aging
A1 Vilas Martínez, Jéssica María
A1 Carneiro Freire, María del Carmen
A1 Silva Álvarez, Sabela da
A1 Ferreirós, Alba
A1 González, Patricia
A1 Gómez, María
A1 Ortega, Sagrario
A1 Serrano, Manuel
A1 García-Caballero Parada, Tomás
A1 González Barcia, Luis
A1 Vidal Figueroa, Anxo
A1 Collado Rodríguez, Manuel
K1 Sox2
K1 Aging
K1 Adult stem cells
K1 Stem cell exhaustion
AB Aging is characterized by a gradual functional decline of tissues with age. Adult stem and progenitor cells are responsible for tissue maintenance, repair, and regeneration, but during aging, this population of cells is decreased or its activity is reduced, compromising tissue integrity and causing pathologies that increase vulnerability, and ultimately lead to death. The causes of stem cell exhaustion during aging are not clear, and whether a reduction in stem cell function is a cause or a consequence of aging remains unresolved. Here, we took advantage of a mouse model of induced adult Sox2+ stem cell depletion to address whether accelerated stem cell depletion can promote premature aging. After a short period of partial repetitive depletion of this adult stem cell population in mice, we observed increased kyphosis and hair graying, and reduced fat mass, all of them signs of premature aging. It is interesting that cellular senescence was identified in kidney after this partial repetitive Sox2+ cell depletion. To confirm these observations, we performed a prolonged protocol of partial repetitive depletion of Sox2+ cells, forcing regeneration from the remaining Sox2+ cells, thereby causing their exhaustion. Senescence specific staining and the analysis of the expression of genetic markers clearly corroborated that adult stem cell exhaustion can lead to cellular senescence induction and premature aging
PB Wiley
YR 2018
FD 2018-08-20
LK http://hdl.handle.net/10347/17640
UL http://hdl.handle.net/10347/17640
LA eng
NO Vilas, J., Carneiro, C., Da Silva-Álvarez, S., Ferreirós, A., González, P., & Gómez, M. et al. (2018). Adult Sox2+ stem cell exhaustion in mice results in cellular senescence and premature aging. Aging Cell, 17(5), e12834. doi: 10.1111/acel.12834
NO Work in the laboratory of M.C. is funded by an ISCIII and EU‐FEDER grant (PI14/00554)
DS Minerva
RD 24 abr 2026