RT Dissertation/Thesis
T1 Design and evaluation of sphingomyelin nanosystems for the development of anticancer targeted therapies
A1 López Bouzo, Belén
K1 Nanosistemas
K1 Esfingomielina
K1 Cáncer
AB In the era of personalized medicine, the rational design of nanosystems has become a keyelement to provide more effective and powerful treatments in cancer therapy. This thesisdisclosed a new nanoplatform, based on sphingomyelin in combination with an oil, which issimple in composition, easy to produce, stable, biocompatible, highly versatile and suitable forthe association of different drugs and molecules. An in silico-in vitro approach has allowed usto gather extensive knowledge regarding the fundamental interactions governing the assemblyof the nanosystem, as well as the interactions with several selected drugs. Subsequentexperiments were carried out to assess the potential application of this nanoplatform forcancer therapy exploring two main approaches, a gene delivery strategy and the developmentof a targeted combination therapy. Altogether, the results show a nanoplatform with adequatephysicochemical, biopharmaceutical, and functional properties, with potential for thedevelopment of improved anticancer therapeutics.
YR 2019
FD 2019
LK http://hdl.handle.net/10347/20075
UL http://hdl.handle.net/10347/20075
LA eng
DS Minerva
RD 28 abr 2026