RT Journal Article
T1 Dual Drug Release of Triamterene and Aminophylline from Poly (N-Isopropylacrylamide) Hydrogels
A1 Castro Otero, Emilio
A1 Mosquera Tallón, Víctor
A1 Katime, Issa
K1 Drug delivery systems
K1 Hydrogels
K1 Polyamides
K1 Diffusion
K1 UV-Vis spectroscopy
AB We used temperature-sensitive poly(N-isopropylacrylamide) hydrogels as drug delivery systems, so changes in body temperature induced by pathogens could act like external stimuli to activate controlled release of the drugs incorporated in the hydrogel. In the distilled water combined release studies, we chose two model drugs: aminophylline and triamterene. The amount of drug released was measured by UV-Vis spectroscopy following the evolution of the absorption peaks of aminophylline (271 nm) and triamterene (365 nm). The maximum release time was greater for triamterene than for aminophylline at 37 °C, so these time-release profiles enabled the active ingredients to work over different periods of time. By increasing molar mass or solubility of the drug, we observed that the diffusion coefficient decreased. On the contrary, increasing hydrophobicity of the drug leads to a diffusion coefficient increase. The evolution of pore size distribution of hydrogels during loading and releasing was measured by quasi-elastic light scattering and by environmental electronic scanning microscope. When loading and releasing the drugs, the pore size of the hydrogel decreased and increased again without reaching the initial pore size of the hydrogel, respectively. We observed that the greater the concentration of drug loaded into the hydrogel, the greater the reduction in pore size.
PB Sage Publications
SN 1847-9804
YR 2012
FD 2012
LK http://hdl.handle.net/10347/21998
UL http://hdl.handle.net/10347/21998
LA eng
NO Castro, E., Mosquera, V., & Katime, I. (2012). Dual Drug Release of Triamterene and Aminophylline from Poly (N-Isopropylacrylamide) Hydrogels. "Nanomaterials and Nanotechnology".
NO The authors thank Ministerio de Ciencia e Innovación (MICINN) for projects MAT2010‐21509‐C03‐02, ACI2008‐0789 and Gobierno Vasco (Grupo Consolidado). E.C. acknowledges the Angeles Alvariño (Xunta de Galicia, Spain, and FSE, European Union) programme
DS Minerva
RD 27 abr 2026