RT Journal Article
T1 Self-Assembled Micro-Fibres by Oxime Connection of Linear Peptide Amphiphiles
A1 Booth, Richard
A1 Insua López, Ignacio
A1 Bhak, Ghibom
A1 Montenegro García, Javier
AB Linear peptide amphiphiles are excellent biocompatible scaffolds for the hierarchical self-assembly of one dimensional nanostructuresin aqueous media. However, their structural exploration and screening of self-assembling properties is oftenlimited by time-consuming synthesis and purification steps. We here describe the application of the oxime bond as apowerful synthetic tool towards the conjugation of peptide heads bearing a hydroxylamine group with hydrophobicaldehyde tails. This methodology allowed the quick prepraration of a small library of oxime-connected peptide amphiphiles,whose supramolecular screening revealed nano-to-micro fibrillation with dependency on their chemical structure. Theseresults demonstrate the simplicity and the synthetic potential of the oxime conjugation for the preparation of peptideamphiphiles with improved self-assembling capabilities
PB Royal Society of Chemistry
SN 1477-0520
YR 2018
FD 2018
LK http://hdl.handle.net/10347/17628
UL http://hdl.handle.net/10347/17628
LA eng
NO Booth, R., Insua, I., Bhak, G., & Montenegro, J. (2018). Self-Assembled Micro-Fibres by Oxime Connection of Linear Peptide Amphiphiles. Organic & Biomolecular Chemistry. doi: 10.1039/c8ob02243g
NO This work was partially supported by the Spanish Agencia Estatal de Investigación (AEI) [CTQ2014-59646-R, SAF2017-89890-R], the Xunta de Galicia (ED431G/09, ED431C 2017/25 and 2016-AD031) and the ERDF. I.I. thanks the Spanish AEI for a Juan de la Cierva -Formación fellowship (FJCI-2017-31795). J.M. received a Ramón y Cajal (RYC-2013-13784), an ERC Starting Investigator Grant (DYNAP-677786) and a Young Investigator Grant from the Human Frontier Science Research Program (RGY0066/2017)
DS Minerva
RD 28 abr 2026