RT Journal Article
T1 Conditioned Pain Modulation (CPM) Paradigms: Reliability and Relationship With Individual Characteristics
A1 Gil Ugidos, Antonio
A1 Rubal-Otero, Lara
A1 González Villar, Alberto Jacobo
A1 Carrillo de la Peña, María Teresa
K1 Central pain biomarkers
K1 Conditioned pain modulation (CPM)
K1 Quantitative sensory testing (QST)
K1 Reliability
K1 Temporal summation of second pain (TSSP)
AB Purpose: Conditioned Pain Modulation (CPM) is a useful tool for testing the functionality of endogenous pain modulation. However, inconsistent results have been obtained in clinical populations, possibly due to the wide variety of CPM protocols used and the influence of demographic and psychological charac teristics of the individuals assessed. Methods: We tested the sensitivity and reliability of four commonly used CPM paradigms in a sample of 58 healthy participants. We also checked how these measures were related to Temporal Summation of Second Pain (TSSP), sociodemographic (age and sex) and psychological variables (anxiety and stress). Results: CPM results were influenced by the test stimulus used, with tests using pain pressure threshold (PPT) obtaining a greater number of responders (over 65%) and being the most sensitive (higher size effect: Cohen’s d > 0.5). However, all measures showed excellent intrasession reliability, with strong agreement between the CPM magnitudes. CPM indices were not correlated with TSSP, age or sex, and the psychological scales did not differentiate CPM responders and non-responders. Conclusions: Although the CPM indices showed good reliability, construction of a large database with standardized values for healthy individuals seems necessary for the use of CPM in clinical settings.
PB Elsevier
SN 1524-9042
YR 2024
FD 2024-12-31
LK https://hdl.handle.net/10347/40754
UL https://hdl.handle.net/10347/40754
LA eng
NO A. Gil-Ugidos, L. Rubal-Otero, A. González-Villar et al. (2024). Conditioned Pain Modulation (CPM) Paradigms: Reliability and Relationship With Individual Characteristics, Pain Management Nursing, https://doi.org/10.1016/j.pmn.2024.12.001
NO This study was funded by the Spanish State Research Agency (Call: Retos 2019. Project reference: PID2019-107986RB-I00). A. Gil-Ugidos was supported by a grant from the Spanish Government (Ministerio de Ciencia e Innovación; grant number PRE2020-091845). Funding for open access charge: Universidade de Santiago de Compostela/CISUG.
DS Minerva
RD 27 abr 2026