RT Journal Article
T1 Association of periodontitis with cognitive decline and its progression: Contribution of blood‐based biomarkers of Alzheimer's disease to this relationship
A1 Carballo, Álvaro
A1 López‐Dequidt, Iria
A1 Custodia Malvido, Antía
A1 Botelho, João
A1 Aramburu‐Núñez, Marta
A1 Machado, Vanessa
A1 Pías‐Peleteiro, Juan Manuel
A1 Ouro Villasante, Alberto
A1 Romaus-Sanjurjo, Daniel
A1 Vázquez‐Vázquez, Laura
A1 Jiménez‐Martín, Isabel
A1 Aguiar Fernández, Pablo
A1 Rodríguez‐Yáñez, Manuel
A1 Aldrey, José Manuel
A1 Blanco Carrión, Juan
A1 Castillo Sánchez, José Antonio
A1 Sobrino, Tomás
A1 Leira Feijóo, Yago
K1 Amyloid beta peptides
K1 Biomarkers
K1 Dementia
K1 Periodontitis
K1 Tau protein
AB AimTo assess whether periodontitis is associated with cognitive decline and its progression as well as with certain blood-based markers of Alzheimer's disease.Materials and MethodsData from a 2-year follow-up prospective cohort study (n = 101) was analysed. Participants with a previous history of hypertension and aged ≥60 years were included in the analysis. All of them received a full-mouth periodontal examination and cognitive function assessments (Addenbrooke's Cognitive Examination (ACE) and Mini-Mental State Examination [MMSE]). Plasma levels of amyloid beta (Aβ)1-40, Aβ1-42, phosphorylated and total Tau (p-Tau and t-Tau) were determined at baseline, 12 and 24 months.ResultsPeriodontitis was associated with poor cognitive performance (MMSE: β = −1.5 [0.6]) and progression of cognitive impairment (hazard ratio [HR] = 1.8; 95% confidence interval: 1.0–3.1). Subjects with periodontitis showed greater baseline levels of p-Tau (1.6 [0.7] vs. 1.2 [0.2] pg/mL, p < .001) and Aβ1-40 (242.1 [77.3] vs. 208.2 [73.8] pg/mL, p = .036) compared with those without periodontitis. Concentrations of the latter protein also increased over time only in the periodontitis group (p = .005).ConclusionsPeriodontitis is associated with cognitive decline and its progression in elderly patients with a previous history of hypertension. Overexpression of p-Tau and Aβ1-40 may play a role in this association
PB Wiley
SN 0303-6979
YR 2023
FD 2023-08-16
LK http://hdl.handle.net/10347/31240
UL http://hdl.handle.net/10347/31240
LA eng
NO Journal of Clinical Periodontology, 50(11), 1444–1454
NO This study was partially supported by grants from the Xunta de Galicia (TS & JC: IN607A2018/3, TS: IN607D 2020/09 and IN607A2022/07), Institute of Health Carlos III (TS: PI22/00938 and CB22/05/00067) and Spanish Ministry of Science (TS: RTI2018-102165-B-I00 and RTC2019-007373-1). Furthermore, this study was also supported by grants from the INTERREG Atlantic Area (TS: EAPA_791/2018_NEUROATLANTIC project), INTER-REG V A España Portugal (POCTEP) (TS: 0624_2IQBIONEURO_6_E) and the European Regional Development Fund. Moreover, several members of the research team are supported by the Institute of Health Carlos III: MAN holds an iPFIS contract (IFI18/00008), DR-S and YL are recipients of a Sara Borrell fellowship (CD21/00166 and CD22/00051, respectively) and TS held a Miguel Servet contract (CPII17/00027). Finally, AC is supported by a predoc contract of Xunta de Galicia (IN606A-2021/015). The funders had no role in the study design, data collection and analysis, decision to publish or preparation of the manuscript
DS Minerva
RD 28 abr 2026