RT Journal Article
T1 Salivary biomarkers for cancer diagnosis: a meta-analysis
A1 Rapado González, Óscar
A1 Martínez-Reglero, Cristina
A1 Salgado-Barreira, Ángel
A1 Takkouche, Bahi
A1 López López, Rafael
A1 Suárez Cunqueiro, María Mercedes
A1 Muinelo-Romay, Laura
K1 saliva
K1 salivary biomarkers
K1 salivaomics
K1 cancer
K1 diagnosis
K1 liquid biopsy
K1 meta-analysis
AB Background: Saliva represents a promising non-invasive source of novel biomarkers for diagnosis and prognosis cancer. This meta-analysis evaluates the diagnostic value of salivary biomarkers for detection of malignant non-oral tumours to better define the value of saliva as an alternative liquid biopsy. Materials and methods: We performed a systematic review and meta-analysis. PubMed, Embase, LILACS and the Cochrane Library were searched to identify articles that examined the potential of salivary biomarkers for the diagnosis of malignant non-oral tumours. To assess the overall accuracy, we calculated the diagnostic odds ratio (DOR), area under hierarchical summary receiver operating characteristic (AUC) curve, sensitivity, specificity, positive likelihood ratio (PLR) and negative likelihood ratio (NLR) using a random- or fixed-effects model. Heterogeneity and publication bias were assessed. Statistical tests were two-sided. Results: One hundred fifty-five study units from 29 articles with 11,153 subjects were included. The pooled sensitivity, specificity, PLR, NLR, DOR and AUC were 0.76 (95% confidence intervals (CI), 0.74–0.77), 0.76 (95% CI, 0.75–0.77), 3.22 (95% CI, 2.92–3.55), 0.31 (95% CI, 0.28–0.34), 13.42 (95% CI, 12.28–15.96) and 0.85 (95% CI, 0.84–0.87), respectively. Conclusion: Salivary biomarkers may be potentially used for non-invasive diagnosis of malignant non-oral tumours.
PB Taylor and Francis
SN 0785-3890
YR 2020
FD 2020-04-11
LK https://hdl.handle.net/10347/43762
UL https://hdl.handle.net/10347/43762
LA eng
NO Rapado-González, Ó., Martínez-Reglero, C., Salgado-Barreira, Á., Takkouche, B., López-López, R., Suárez-Cunqueiro, M. M., & Muinelo-Romay, L. (2020). Salivary biomarkers for cancer diagnosis: a meta-analysis. Annals of Medicine, 52(3–4), 131–144. https://doi.org/10.1080/07853890.2020.1730431
DS Minerva
RD 27 abr 2026