RT Dissertation/Thesis
T1 Preparation and characterization of antigen loaded chitosan nanoparticles for immunization
A1 Prasanna, Maruthi
K1 Glycoconjugate
K1 Chitosan
K1 Nanoparticles
K1 Vaccines
K1 PsaA
K1 Pneumonia
AB The currently available pneumococcal vaccines are not effective in completeprevention of pneumococcal infections. To develop a better vaccine, firstly, we produced a glycoconjugate antigenbased on common pneumococcal vaccine. Based on the positive immune responses generated by theglycoconjugate antigen in the mice, we further envisage that their combination with the nanotechnologies wouldgenerate a vaccine with enhanced potential. In this line, we utilized chitosan nanoparticles to encapsulate theglycoconjugate. Finally, the developed nanovaccines generated an enhanced immune response against both theprotein and polysaccharide components when compared to the naked glycoconjugate.
YR 2020
FD 2020
LK http://hdl.handle.net/10347/24042
UL http://hdl.handle.net/10347/24042
LA eng
DS Minerva
RD 22 abr 2026