RT Journal Article
T1 Hypothalamus-liver talks: whispers in the language of metabolism
A1 Ferreira, Vitor
A1 Fernández González, Iara
A1 Vattathara, Jane Jose
A1 Rodríguez Díaz, Amanda
A1 Fernández Sanmartín, Paola
A1 Diéguez González, Carlos
K1 Hypothalamus
K1 Liver disease
K1 Obesity
K1 Diabetes
K1 Insulin
K1 Amylin
K1 Glucagon
K1 GLP-1
K1 FGF21
AB Closely associated with the exponential increase of obesity and sedentary life, liver-related disorders are a major global health concern. Recent data suggest that the global prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) among adults is of 32% and 5.1% for alcohol-related liver disease, with hepatic disorders contributing to 4% of global mortality, accounting for approximately 2 million deaths annually. Over the past two decades, the hypothalamus has emerged as a central hub in regulating whole body metabolic and energy homeostasis. Nevertheless, the interactome between the hypothalamus and the liver in the progression of liver metabolic dysfunctions, as well as its potential as a therapeutic target, remains poorly understood. In this review, we provide a comprehensive overview of the current knowledge regarding the hypothalamus-liver crosstalk, with a particular emphasis on the mechanisms underlying it. We explore how signals transmitted by different hormones can modulate these interactions, shedding light on their functional implications for hepatic regulation and systemic homeostasis through central signals.
PB Springer
YR 2026
FD 2026-03-19
LK https://hdl.handle.net/10347/46879
UL https://hdl.handle.net/10347/46879
LA eng
NO Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. The research group has received support from: Ministerio de Ciencia e Innovación co-funded by the FEDER Program of EU (CD: PID2023-149533NB-I00). CiMUS, and the researchers, were supported by the Xunta de Galicia (2020– 2023, ED431G/05; ED431C 2025/24). CIBER de Fisiopatología de la Obesidad y Nutrición is an initiative of ISCIII. VF is a recipient of a Juan de la Cierva contract (JDC2023-051969-I, AEI, Spain). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
DS Minerva
RD 6 may 2026