RT Journal Article
T1 Effects of aluminium on rat brain mitochondria bioenergetics: an in vitro and in vivo study
A1 Iglesias González, Javier
A1 Sánchez Iglesias, Sofía
A1 Beiras Iglesias, Andrés
A1 Méndez Álvarez, Estefanía
A1 Soto-Otero, Ramón
K1 Aluminium
K1 Mitochondria
K1 High-resolution respirometry
K1 Parkinson's disease
K1 Oxidative stress
K1 Rat brain
AB Numerous studies have highlighted the potential of aluminium as an aetiological factor for some neurodegenerative disorders, particularly Alzheimer’s disease and Parkinson’s disease. Our previous studies have shown that aluminium can cause oxidative stress, reduce the activity of some antioxidant enzymes, and enhance the dopaminergic neurodegeneration induced by 6-hydroxydopamine in an experimental model of Parkinson’s disease in rats. We now report a study on the effects caused by aluminium on mitochondrial bioenergetics following aluminium addition and after its chronic administration to rats. To develop our study, we used a high-resolution respirometry to test the mitochondrial respiratory capacities under the conditions of coupling, uncoupling, and non-coupling. Our study showed alterations in leakiness, a reduction in the maximum capacity of complex II-linked respiratory pathway, a decline in the respiration efficiency, and a decrease in the activities of complexes III and V in both models studied. The observed effects also included both an alteration in mitochondrial transmembrane potential and a decrease in oxidative phosphorylation capacity when relatively high concentrations of aluminium were added to the isolated mitochondria. These findings contribute to explain both the ability of aluminium to generate oxidative stress and its suggested potential to act as an etiological factor by promoting the progression of neurodegenerative disorders such as Parkinson’s disease.
PB Springer
YR 2017
FD 2017
LK http://hdl.handle.net/10347/32559
UL http://hdl.handle.net/10347/32559
LA eng
NO Iglesias-González, J., Sánchez-Iglesias, S., Beiras-Iglesias, A. et al. Effects of Aluminium on Rat Brain Mitochondria Bioenergetics: an In vitro and In vivo Study. Mol Neurobiol 54, 563–570 (2017)
NO This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s12035-015-9650-z
NO This study was financially supported by grant 09CSA005298PR from the Galician Government (XUGA), Santiago de Compostela, Spain.
DS Minerva
RD 22 abr 2026