RT Journal Article
T1 Mucosal antibody responses to vaccines targeting SIV protease cleavage sites or full-length Gag and Env proteins in Mauritian cynomolgus macaques
A1 Li, Hongzhao
A1 Hai, Yan
A1 Lim, So-Yon
A1 Toledo, Nikki
A1 Crecente Campo, José
A1 Schalk, Dane
A1 Li, Lin
A1 Omange, Robert W.
A1 Gómez Dacoba, Tamara
A1 Liu, Lewis R.
A1 Kashem, Mohammad Abul
A1 Wan, Yanmin
A1 Liang, Binhua
A1 Li, Qingsheng
A1 Rakasz, Eva
A1 Schultz-Darken, Nancy
A1 Alonso Fernández, María José
A1 Plummer, Francis A.
A1 Whitney, James B.
A1 Luo, Ma
AB HIV mutates rapidly and infects CD4+ T cells, especially when they are activated. A vaccine targeting conserved, essential viral elements while limiting CD4+ T cell activation could be effective. Learning from natural immunity observed in a group of highly HIV-1 exposed seronegative Kenyan female sex workers, we are testing a novel candidate HIV vaccine targeting the 12 viral protease cleavage sites (PCSs) (the PCS vaccine), in comparison with a vaccine targeting full-length Gag and Env (the Gag/Env vaccine) in a Mauritian cynomolgus macaque/SIV model. In this study we evaluated these vaccines for induction of mucosal antibodies to SIV immunogens at the female genital tract. Bio-Plex and Western blot analyses of cervicovaginal lavage samples showed that both the PCS and Gag/Env vaccines can elicit mucosal IgG antibody responses to SIV immunogens. Significantly higher increase of anti-PCS antibodies was induced by the PCS vaccine than by the Gag/Env vaccine (p<0.0001). The effect of the mucosal antibody responses in protection from repeated low dose pathogenic SIVmac251 challenges is being evaluated
PB PLOS
YR 2018
FD 2018
LK http://hdl.handle.net/10347/21609
UL http://hdl.handle.net/10347/21609
LA eng
NO Li H, Hai Y, Lim S-Y, Toledo N, Crecente-Campo J, Schalk D, et al. (2018) Mucosal antibody responses to vaccines targeting SIV protease cleavage sites or full-length Gag and Env proteins in Mauritian cynomolgus macaques. PLoS ONE 13(8): e0202997. https://doi.org/10.1371/journal.pone.0202997
NO This work was supported by a NIH grant (R01AI111805), a CIHR/CHVI bridging grant and funding from National Microbiology Laboratory of Canada
DS Minerva
RD 27 abr 2026