RT Journal Article
T1 Intracellular Ruthenium‐Promoted (2+2+2) Cycloadditions
A1 Miguel Ávila, Joan
A1 Tomás Gamasa, María
A1 Mascareñas Cid, José Luis
K1 Alkynes
K1 Biological chemistry
K1 Cycloadditions
K1 Intracellular chemistry
K1 Ruthenium
AB Metal‐mediated intracellular reactions are becoming invaluable tools in chemical and cell biology, and hold promise for strongly impacting the field of biomedicine. Most of the reactions reported so far involve either uncaging or redox processes. Demonstrated here for the first time is the viability of performing multicomponent alkyne cycloaromatizations inside live mammalian cells using ruthenium catalysts. Both fully intramolecular and intermolecular cycloadditions of diynes with alkynes are feasible, the latter providing an intracellular synthesis of appealing anthraquinones. The power of the approach is further demonstrated by generating anthraquinone AIEgens (AIE=aggregation induced emission) that otherwise do not go inside cells, and by modifying the intracellular distribution of the products by simply varying the type of ruthenium complex
PB Wiley
SN 1433-7851
YR 2020
FD 2020
LK http://hdl.handle.net/10347/23368
UL http://hdl.handle.net/10347/23368
LA eng
NO J. Miguel-Ávila, M. Tomás-Gamasa, J. L. Mascareñas, Angew. Chem. Int. Ed. 2020, 59, 17628
NO This is the peer reviewed version of the following article: J. Miguel-Ávila, M. Tomás-Gamasa, J. L. Mascareñas, Angew. Chem. Int. Ed. 2020, 59, 17628, which has been published in final form at https://doi.org/10.1002/anie.202006689. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions
NO This work has received financial support from the Spanish Government (SAF2016‐76689‐R, ORFEO‐CINQA network CTQ2016‐81797‐REDC) the Consellería de Cultura, Educación e Ordenación Universitaria (2015‐CP082, ED431C‐2017/19 and Centro Singular de Investigación de Galicia Accreditation 2019–2022, ED431G 2019/03), the European Union (European Regional Development Fund‐ERDF corresponding to the multiannual financial framework 2014–2020), and the European Research Council (Advanced Grant No. 340055). J.M.Á. thanks the Ministerio de Educación, Cultura y Deporte for the FPU fellowship (FPU16/00711) and M.T.G. thanks the financial support from the Agencia Estatal de Investigación (RTI2018‐093813‐J‐I00)
DS Minerva
RD 27 abr 2026