RT Journal Article
T1 Laccase-catalyzed degradation of anti-inflammatories and estrogens
A1 Lloret, Lucía
A1 Eibes González, Gemma María
A1 Lu Chau, Thelmo Alejandro
A1 Moreira Vilar, María Teresa
A1 Feijoo Costa, Gumersindo
A1 Lema Rodicio, Juan Manuel
K1 Laccase
K1 Estrogens
K1 Anti-inflammatories
K1 Natural mediators
K1 PH
K1 Myceliophthora thermophila
AB Pharmaceuticals are regarded as emerging environmental pollutants since many of them are ubiquitous, recalcitrant and biologically active. In this paper, the degradation of several pharmaceuticals such as anti-inflammatory drugs (diclofenac and naproxen) and estrogen hormones (estrone, 17β-estradiol, 17α-ethinylestradiol) was assessed by means of the commercial laccase (Lac) from Myceliophthora thermophila. The influence of different mediators (synthetic and natural) and their concentration on the Lac-based oxidation system were evaluated. Estrogens were completely degraded after only 15 min while the other types of pharmaceuticals presented higher persistence since 1 h of incubation was required for total removal of diclofenac and 8 h to attain up to 60% of naproxen degradation. Among the different natural mediators, syringaldehyde greatly enhanced the action of the Lac, similarly to the synthetic mediator 1-hydroxibenzotriazole (HBT) in the case of estrogens and diclofenac. The other natural mediators presented significantly high efficiency, obtaining removal percentages ranging from 80% to 100% after 24 h of enzymatic reaction.
PB Elsevier
SN 1369-703X
YR 2010
FD 2010-09-15
LK https://hdl.handle.net/10347/39259
UL https://hdl.handle.net/10347/39259
LA eng
NO L. Lloret, G. Eibes, T.A. Lú-Chau, M.T. Moreira, G. Feijoo, J.M. Lema, Laccase-catalyzed degradation of anti-inflammatories and estrogens, Biochemical Engineering Journal, Volume 51, Issue 3, 2010, Pages 124-131, ISSN 1369-703X, https://doi.org/10.1016/j.bej.2010.06.005.
DS Minerva
RD 24 abr 2026