RT Journal Article
T1 Obesity-hypoventilation syndrome: increased risk of death over sleep apnea syndrome
A1 Castro Añón, Olalla
A1 Pérez de Llano, Luis A.
A1 Fuente Sánchez, Sandra de la
A1 Golpe, Rafael
A1 Méndez Marote, Lidia
A1 Castro Castro, Julián
A1 González Quintela, Arturo
AB Aim: To study whether mortality and cardiovascular morbidity differ in non-invasive ventilation (NIV)-treated patients with severe obesity-hypoventilation syndrome (OHS) as compared with CPAP-treated patients with obstructive sleep apnea syndrome (OSAS), and to identify independent predictors of mortality in OHS.Material and methods: Two retrospective cohorts of OHS and OSAS were matched 1:2 according to sex, age (±10 year) and length of time since initiation of CPAP/NIV therapy (±6 months).Results: Three hundred and thirty subjects (110 patients with OHS and 220 patients with OSAS) were studied. Mean follow-up time was 7±4 years. The five year mortality rates were 15.5% in OHS cohort and 4.5% in OSAS cohort (p< 0.05). Patients with OHS had a 2-fold increase (OR 2; 95% CI: 1.11–3.60) in the risk of mortality and 1.86 fold (OR 1.86; 95% CI: 1.14–3.04) increased risk of having a cardiovascular event. Diabetes, baseline diurnal SaO2 < 83%, EPAP < 7 cmH2O after titration and adherence to NIV < 4 hours independently predicted mortality in OHS.Conclusion: Mortality of severe OHS is high and substantially worse than that of OSAS. Severe OHS should be considered a systemic disease that encompasses respiratory, metabolic and cardiovascular components that require a multimodal therapeutic approach.
PB PLOS
YR 2015
FD 2015
LK http://hdl.handle.net/10347/21735
UL http://hdl.handle.net/10347/21735
LA eng
NO Castro-Añón O, Pérez de Llano LA, De la Fuente Sánchez S, Golpe R, Méndez Marote L, Castro-Castro J, et al. (2015) Obesity-Hypoventilation Syndrome: Increased Risk of Death over Sleep Apnea Syndrome. PLoS ONE 10(2): e0117808. https://doi.org/10.1371/journal.pone.0117808
DS Minerva
RD 24 abr 2026