RT Journal Article
T1 Antibacterial activity and molecular docking studies of a selected series of Hydroxy-3-arylcoumarins
A1 Pisano, Maria Barbara
A1 Kumar, Amit
A1 Medda, Rosaria Medda
A1 Gatto, Gianluca
A1 Pal, Rajesh
A1 Fais, Antonella
A1 Era, Benedetta
A1 Cosentino, Sofia
A1 Uriarte Villares, Eugenio
A1 Santana Penín, María Lourdes
A1 Pintus, Francesca
A1 Matos, Maria João Correia Pinto Carvalho de
K1 Hydroxy-3-arylcoumarins
K1 Perkin–Oglialoro reaction
K1 Antibacterial activity
K1 Molecular docking
AB Antibiotic resistance is one of the main public health concerns of this century. Thisresistance is also associated with oxidative stress, which could contribute to the selection of resistantbacterial strains. Bearing this in mind, and considering that flavonoid compounds are well known fordisplaying both activities, we investigated a series of hydroxy-3-arylcoumarins with structural featuresof flavonoids for their antibacterial activity against different bacterial strains. Active compoundsshowed selectivity against the studied Gram-positive bacteria compared to Gram-negative bacteria.5,7-Dihydroxy-3-phenylcoumarin (compound 8) displayed the best antibacterial activity againstStaphylococcus aureus and Bacillus cereus with minimum inhibitory concentrations (MICs) of 11 µg/mL,followed by Staphylococcus aureus (MRSA strain) and Listeria monocytogenes with MICs of 22 and44 µg/mL, respectively. Moreover, molecular docking studies performed on the most active compoundsagainst Staphylococcus aureus tyrosyl-tRNA synthetase and topoisomerase II DNA gyrase revealedthe potential binding mode of the ligands to the site of the appropriate targets. Preliminarystructure–activity relationship studies showed that the antibacterial activity can be modulated by thepresence of the 3-phenyl ring and by the position of the hydroxyl groups at the coumarin scaffold
PB MDPI
YR 2019
FD 2019
LK http://hdl.handle.net/10347/22384
UL http://hdl.handle.net/10347/22384
LA eng
NO Pisano, M.B., Kumar, A., Medda, R., Gatto, G., Pal, R., Fais, A., Era, B., Cosentino, S., Uriarte, E., Santana, L., Pintus, F., Matos, M.J. (2019). Antibacterial activity and molecular docking studies of a selected series of Hydroxy-3-arylcoumarins. Molecules 24(15), 2815. doi: 10.3390/molecules24152815
NO This work was partially supported by a grant from the University of Cagliari (FIR) and by Galician Plan of Research, Innovation and Growth 2011–2015 (Xunta da Galicia Plan I2C, ED481B 2014/086–0 and ED481B 2018/007
DS Minerva
RD 24 abr 2026