RT Journal Article
T1 Heart Alterations after Domoic Acid Administration in Rats
A1 Crespo Vieira, Andrés
A1 Cifuentes Martínez, José Manuel
A1 Bermúdez Pose, Roberto
A1 Fernández Ferreiro, Sara
A1 Román Castro, Albina
A1 Botana López, Luis Miguel
K1 Cardiotoxicity
K1 Domoic acid
K1 Electron microscopy
K1 Immunohistochemistry
K1 Phycotoxin
AB Domoic acid (DA) is one of the best known marine toxins, causative of important neurotoxic alterations. DA effects are documented both in wildlife and experimental assays, showing that this toxin causes severe injuries principally in the hippocampal area. In the present study we have addressed the long-term toxicological effects (30 days) of DA intraperitoneal administration in rats. Different histological techniques were employed in order to study DA toxicity in heart, an organ which has not been thoroughly studied after DA intoxication to date. The presence of DA was detected by immunohistochemical assays, and cellular alterations were observed both by optical and transmission electron microscopy. Although histological staining methods did not provide any observable tissue damage, transmission electron microscopy showed several injuries: a moderate lysis of myofibrils and loss of mitochondrial conformation. This is the first time the association between heart damage and the presence of the toxin has been observed
PB MDPI AG
YR 2016
FD 2016-03-10
LK http://hdl.handle.net/10347/16251
UL http://hdl.handle.net/10347/16251
LA eng
NO Vieira, A.C.; Cifuentes, J.M.; Bermúdez, R.; Ferreiro, S.F.; Castro, A.R.; Botana, L.M. Heart Alterations after Domoic Acid Administration in Rats. Toxins 2016, 8, 68
NO The research leading to these results has received funding from the following FondoEuropeo de Desarrollo Regional (FEDER) cofunded-grants. From Centro para el Desarrollo Tecnológico eIndustrial (CDTI) and Technological Funds, supported by Ministerio de Economía y Competitividad, ProgramaNacional de Recursos y Tecnologías Agroalimentarias (AGL) AGL2012-40185-CO2-01, AGL2014-58210-R, andConsellería de Cultura, Educación e Ordenación Universitaria, GRC2013-016. From CDTI under India & SpainInnovating Program (ISIP) Programme, Spain, IDI-20130304 APTAFOOD. From the European Union’s SeventhFramework Programme managed by REA—Research Executive Agency (FP7/2007-2013) under grant agreement312184 PHARMASEA
DS Minerva
RD 28 abr 2026