RT Journal Article
T1 Reversible supramolecular assembly at specific DNA sites: Ni-promoted, bivalent DNA binding with designed peptide and bipyridylbisbenzamidine components
A1 Sánchez López, Mateo Isidro
A1 Mosquera Mosquera, Jesús
A1 Vázquez Sentís, Marco Eugenio
A1 Mascareñas Cid, José Luis
K1 DNA recognition
K1 Minor-groove binders
K1 Peptides
K1 Self-assembly
K1 Supramolecular chemistry
AB At specific DNA sites, nickel(II) salts promote the assembly of designed components, namely a bis(histidine)-modified peptide that is derived from a bZIP transcription factor and a bis(benzamidine) unit that is equipped with a bipyridine. This programmed supramolecular system with emergent properties reproduces some key characteristics of naturally occurring DNA-binding proteins, such as bivalence, selectivity, responsiveness to external agents, and reversibility.
PB WILEY-VCH Verlag GmbH
SN 1521-3773
YR 2014
FD 2014-07-15
LK http://hdl.handle.net/10347/11965
UL http://hdl.handle.net/10347/11965
LA eng
NO Sánchez, M. I., Mosquera, J., Vázquez, M. E. and Mascareñas, J. L. (2014), Reversible Supramolecular Assembly at Specific DNA Sites: Nickel-Promoted Bivalent DNA Binding with Designed Peptide and Bipyridyl–Bis(benzamidine) Components. Angew. Chem. Int. Ed., 53: 9917–9921. doi: 10.1002/anie.201405726
NO We are thankful for support from Spanish grants (SAF2010-20822-C02 and CTQ2012-31341), Consolider Ingenio 2010 (CSD2007-00006), the Xunta de Galicia (GRC2013-041, INCITE09 209084PR, and PGIDIT08CSA-047209PR), the ERDF, and the European Research Council (Advanced Grant 340055). J.M. and M.I.S. thank the Spanish MCINN for their Ph.D. fellowships.
DS Minerva
RD 28 abr 2026