RT Dissertation/Thesis
T1 Neurotoxicity Induced by Oxidative Stress and Aluminium in Relation to Parkinson’s Disease: A Mitochondrial Bioenergetic Approach by High‐Resolution Respirometry
A1 Iglesias González, Javier
A2 Universidade de Santiago de Compostela. Facultade de Medicina e Odontoloxía. Departamento de Bioquímica e Bioloxía Molecular, 
K1 Alzheimer
K1 mitocondria
K1 ataxia de Friedreich
K1 esclerosis lateral amiotrófica
K1 concentraciones de metales
AB The study of mitochondria during the last years has revealed that this organelle plays an important role in the development and onset of neurodegenerative disorders such as Parkinson’s disease. The main hallmarks found in post‐mortem studies remark the importance of brain free radicals levels, the alteration in brain metabolic parameters and the presence of xenobiotics like metals for the neurodegenerative processes. Also, any energetic deficit related with the metabolic impairment due to an exposition to toxics or an increase in oxidative stress might be a favorable condition for the onset of Parkinson’s disease. Within this framework, and in order to gain insight in the aetiology of Parkinson’s disease, this Thesis was developed as a bioenergetics study focused to oxidative stress, Parkinson’s disease, and aluminium.
YR 2014
FD 2014-09-03
LK http://hdl.handle.net/10347/11435
UL http://hdl.handle.net/10347/11435
LA eng
DS Minerva
RD 26 abr 2026