RT Journal Article
T1 Synergistic gold and enamine catalysis: intermolecular α-alkylation of aldehydes with allenamides
A1 Fernández Casado, Jaime
A1 Nelson, Ronald
A1 Mascareñas Cid, José Luis
A1 López García, Fernando
K1 Aldehydes
K1 Allenamides
K1 Enantioselectivity
K1 Gold complex
K1 Organocatalyst
AB Aldehydes can be α-alkylated with allenamides by the combined action of an organocatalyst and a gold complex. The reaction requires the simultaneous generation of an enamine and a gold-activated allenamide. Importantly, by using a chiral amine as organocatalyst it is possible to obtain aldehyde products featuring all-carbon quaternary stereocenter at their α-position, with moderate to good levels of enantioselectivity
PB Royal Society of Chemistry
SN 1359-7345
YR 2016
FD 2016-01-08
LK http://hdl.handle.net/10347/14565
UL http://hdl.handle.net/10347/14565
LA eng
NO Fernández-Casado, J., Nelson, R., Mascareñas, J.L. and López, F. (2016), Synergistic gold and enamine catalysis: intermolecular α-alkylation of aldehydes with allenamides. Chem. Commun., 52, 2909-2912  [DOI:10.1039/C5CC09533F]
NO NOTICE: This is the peer reviewed version of the following article: Jaime Fernández-Casado, Ronald Nelson, José L. Mascareñas* and Fernando López* (2016), Synergistic Gold and Enamine Catalysis: Intermolecular α-Alkylation of Aldehydes with Allenamides. ChemComm., 52, 2909-2912 [10.1039/C5CC09533F]. This article may be used for non-commercial purposes in accordance with RSC Terms and Conditions for self-archiving
NO This work was supported by the Spanish MINECO (SAF2013-41943-R), the ERDF, the European Research Council (Adv. Grant No. 340055) and the Xunta de Galicia (GRC2013-041)
DS Minerva
RD 24 abr 2026