RT Journal Article
T1 Antiangiogenic effects of coumarins against cancer: from chemistry to medicine
A1 Majnooni, Mohammad Bagher
A1 Fakhri, Sajad
A1 Smeriglio, Antonella
A1 Trombetta, Domenico
A1 Croley, Courtney R.
A1 Bhattacharyya, Piyali
A1 Sobarzo Sánchez, Eduardo Marcelo
A1 Farzaei, Mohammad Hosein
A1 Bishayee, Anupam
K1 Coumarins
K1 Antiangiogenic
K1 Cancer
K1 Natural agents
K1 Chemistry
K1 Medicine
AB Angiogenesis, the process of formation and recruitment of new blood vessels frompre-existing vessels, plays an important role in the development of cancer. Therefore, the use ofantiangiogenic agents is one of the most critical strategies for the treatment of cancer. In addition,the complexity of cancer pathogenicity raises the need for multi-targeting agents. Coumarins aremulti-targeting natural agents belonging to the class of benzopyrones. Coumarins have severalbiological and pharmacological effects, including antimicrobial, antioxidant, anti-inflammation,anticoagulant, anxiolytic, analgesic, and anticancer properties. Several reports have shownthat the anticancer effect of coumarins and their derivatives are mediated through targetingangiogenesis by modulating the functions of vascular endothelial growth factor as well asvascular endothelial growth factor receptor 2, which are involved in cancer pathogenesis. In thepresent review, we focus on the antiangiogenic effects of coumarins and related structure-activityrelationships with particular emphasis on cancer
PB MDPI
YR 2019
FD 2019
LK http://hdl.handle.net/10347/22349
UL http://hdl.handle.net/10347/22349
LA eng
NO Majnooni, M.B., Fakhri, S., Smeriglio, A., Trombetta, D., Croley, C.R., Bhattacharyya, P., Sobarzo-Sánchez, E., Farzaei, M.H., Bishayee, A. (2019). Antiangiogenic effects of coumarins against cancer: from chemistry to medicine. Molecules 24(23), 4278. doi: 10.3390/molecules24234278
DS Minerva
RD 28 abr 2026