RT Journal Article
T1 The Complexity of TET2 Functions in Pluripotency and Development
A1 García Outeiral, Vera
A1 Parte, Cristina de la
A1 Fidalgo Pérez, Miguel Ángel
K1 TET2
K1 Epigenetic
K1 Epitranscriptomic
K1 Pluripotency
K1 Reprogramming
K1 Development
K1 5hmC
AB Ten-eleven translocation-2 (TET2) is a crucial driver of cell fate outcomes in a myriad of biological processes, including embryonic development and tissue homeostasis. TET2 catalyzes the demethylation of 5-methylcytosine on DNA, affecting transcriptional regulation. New exciting research has provided evidence for TET2 catalytic activity in post-transcriptional regulation through RNA hydroxymethylation. Here we review the current understanding of TET2 functions on both DNA and RNA, and the influence of these chemical modifications in normal development and pluripotency contexts, highlighting TET2 versatility in influencing genome regulation and cellular phenotypes
PB Frontiers
YR 2021
FD 2021-01-18
LK https://hdl.handle.net/10347/38662
UL https://hdl.handle.net/10347/38662
LA eng
NO Garcia-Outeiral V, de la Parte C, Fidalgo M and Guallar D (2021) The Complexity of TET2 Functions in Pluripotency and Development. Front. Cell Dev. Biol. 8:630754. doi: 10.3389/fcell.2020.630754
DS Minerva
RD 24 abr 2026