RT Dissertation/Thesis
T1 Nanocarriers for the oral administration of therapeutic macromolecules
A1 Santalices Ramos, Irene
K1 Oral peptide delivery
K1 Nanocapsules
K1 Nanoemulsions
AB The main goal of this thesis has been the generation of knowledge towards the advancement of the oral administration of peptides. The specific objective has been to study how the composition and surface properties of lipid-based nanocarriers influence i) their capacity to load hydrosoluble peptides and ii) their ability to overcome the biological barriers associated to the oral modality of administration. Throughout this study, we developed a novel mixed nanosystem (nanoemulsion co-existing with micelles) able to load hydrophobically-modified insulin with a 100 % association efficiency. In brief, this nanosystem showed a great stability and miscibility in bio-relevant media, acceptable mucodiffusive properties and ability to interact and enter the intestinal cells, without relevant cytotoxic effects. Interestingly, the promising in vitro behavior of this insulin-loaded nanosystem was translated into a moderate hypoglycemic response (≈ 20−30 %) following intestinal administration to rats.
YR 2018
FD 2018
LK http://hdl.handle.net/10347/18026
UL http://hdl.handle.net/10347/18026
LA eng
DS Minerva
RD 24 abr 2026