RT Journal Article
T1 GM and KM immunoglobulin allotypes in the Galician population: new insights into the peopling of the Iberian Peninsula
A1 Calderón, Rosario
A1 Lodeiro Ainsua, Rosa
A1 Varela López, Tito Antonio
A1 Fariña, José
A1 Ambrosio, Beatriz
A1 Guitard, Evelyne
A1 González Martín, Antonio
A1 Dugoujon, Jean M.
AB Background: The current genetic structure of Iberian populations has presumably been affected by thecomplex orography of its territory, the different people and civilizations that settled there, its ancient andcomplex history, the diverse and persistent sociocultural patterns in its different regions, and also by theeffects of the Iberian Peninsula representing a refugium area after the last glacial maximum. This paperpresents the first data on GM and KM immunoglobulin allotypes in the Galician population and, thus,provides further insights into the extent of genetic diversity in populations settled in the geographicextremes of the Cantabrian region of northern Spain. Furthermore, the genetic relationships of Galicianswith other European populations have been investigated.Results: Galician population shows a genetic profile for GM haplotypes that is defined by the highpresence of the European Mediterranean GM*3 23 5* haplotype, and the relatively high incidence of theAfrican marker GM*1,17 23' 5*. Data based on comparisons between Galician and other Spanishpopulations (mainly from the north of the peninsula) reveal a poor correlation between geographic andgenetic distances (r = 0.30, P = 0.105), a noticeable but variable genetic distances between Galician andBasque subpopulations, and a rather close genetic affinity between Galicia and Valencia, populations whichare geographically separated by a long distance and have quite dissimilar cultures and histories.Interestingly, Galicia occupies a central position in the European genetic map, despite being geographicallyplaced at one extreme of the European continent, while displaying a close genetic proximity to Portugal,a finding that is consistent with their shared histories over centuries.Conclusion: These findings suggest that the population of Galicia is the result of a relatively balancedmixture of European populations or of the ancestral populations that gave rise to them. This wouldsupport the importance of the migratory movements that have taken place in Europe over the course ofrecent human history and their effects on the European genetic landscape.
PB BMC
SN 1471-2156
YR 2007
FD 2007
LK http://hdl.handle.net/10347/22899
UL http://hdl.handle.net/10347/22899
LA eng
NO Calderón, R., Lodeiro, R., Varela, T.A. et al. GM and KM immunoglobulin allotypes in the Galician population: new insights into the peopling of the Iberian Peninsula. BMC Genet 8, 37 (2007). https://doi.org/10.1186/1471-2156-8-37
DS Minerva
RD 25 abr 2026