RT Book,_Section
T1 Molecular sieves and Ultrasound assisted Synthesis of Novel 1,3,4-oxadiazole-2-thiones derivatives as potential antifungal Agents
A1 Nikalje, Anna Pratima G.
A1 Nimbalkar, Urja D.
A1 Tupe, Santosh G.
A1 Seijas Vázquez, Julio Antonio
A1 Vázquez Tato, María del Pilar
K1 1,3,4-oxadiazoles
K1 Mannich reaction
K1 Ultrasound–assisted
K1 Molecular sieves
K1 Antifungal activity
AB In the category of microorganism, fungi are considered as the special class of microbes responsible for opportunistic pathogenic infections in humans species. Due to the side effects of commercially available  antifungal drugs  and the emergence of new drug resistant fungal species in the past few years  has forced the researchers to search for  novel and efficient antifungal drug molecules. The 1,3,4-oxadiazoles scaffold is associated with diverse biological activities. The multipurpose use of the Mannich bases in pharmaceutical chemistry provoked us to prepare a new series of 1,3,4-oxadiazole Mannich bases derivatives, as antifungal agents.Herein we report Molecular sieves and Ultrasound assisted synthesis of novel series of Mannich bases of the 5-substituted 1,3,4-oxadiazole-2-thiones  by amino methylation with paraformaldehyde and substituted primary / secondary amines and their  evaluation for antifungal activity .The structures of the newly synthesized compounds were determined by IR, NMR and Mass spectral study. The synthesized compounds exhibited interesting moderate to excellent antifungal activity against Candida albicans (NCIM 3557),Candida albicans(NCIM3471), Candida glabrata(NCIM3237), Cryptococcus neoformans (NCIM 3542),Cryptococcus neoformans(NCIM 3378),Aspergillus fumigates(NCIM 902), Aspergillus niger( NCIM 628) using  Flucanazole as a standard reference drug. The synthesised compounds 6d, 6f ,6g, 6h and 6j exhibited promising antifungal activity as fungi static agents
PB MDPI
SN 978-3-03842-145-0
YR 2015
FD 2015
LK http://hdl.handle.net/10347/25848
UL http://hdl.handle.net/10347/25848
LA eng
NO Nikalje, A.P., Nimbalkar, U., Tupe, S., Seijas Vázquez, J.A. & Vázquez Tato, M.P. (2015). Molecular sieves and Ultrasound assisted Synthesis of Novel 1,3,4-oxadiazole-2-thiones derivatives as potential antifungal Agents. In J.A. Seijas, M.P. Vázquez Tato & S.K. Lin, Proceedings ECSOC-19: The 19Th International Electronic Conference On Synthetic Organic Chemistry: November 1-30, 2016. MDPI. doi: 10.3390/ecsoc-19-b008
NO The 19th International Electronic Conference on Synthetic Organic Chemistry session Bioorganic, Medicinal and Natural Products Chemistry
DS Minerva
RD 29 abr 2026