RT Journal Article
T1 Short-term anti-plaque effect of a cymenol mouthwash analysed using the DenTiUS Deep Plaque software: a randomised clinical trial
A1 Suárez Rodríguez, Berta
A1 Regueira Iglesias, Alba
A1 Blanco Pintos, Triana
A1 Balsa Castro, Carlos
A1 Vila Blanco, Nicolás
A1 Carreira Nouche, María José
A1 Tomás Carmona, Inmaculada
K1 Cymenol
K1 Mouthwash
K1 Dental plaque
K1 Oral health
K1 Prevention
K1 Image analysis
K1 Automated plaque quantification
AB BackgroundThe effect of cymenol mouthwashes on levels of dental plaque has not been evaluated thus far.ObjectiveTo analyse the short-term, in situ, anti-plaque effect of a 0.1% cymenol mouthwash using the DenTiUS Deep Plaque software.MethodsFifty orally healthy participants were distributed randomly into two groups: 24 received a cymenol mouthwash for eight days (test group A) and 26 a placebo mouthwash for four days and a cymenol mouthwash for a further four days thereafter (test group B). They were instructed not to perform other oral hygiene measures. On days 0, 4, and 8 of the experiment, a rinsing protocol for staining the dental plaque with sodium fluorescein was performed. Three intraoral photographs were taken per subject under ultraviolet light. The 504 images were analysed using the DenTiUS Deep Plaque software, and visible and total plaque indices were calculated (ClinicalTrials ID NCT05521230).ResultsOn day 4, the percentage area of visible plaque was significantly lower in test group A than in test group B (absolute = 35.31 ± 14.93% vs. 46.57 ± 18.92%, p = 0.023; relative = 29.80 ± 13.97% vs. 40.53 ± 18.48%, p = 0.024). In comparison with the placebo, the cymenol mouthwash was found to have reduced the growth rate of the area of visible plaque in the first four days by 26% (absolute) to 28% (relative). On day 8, the percentage areas of both the visible and total plaque were significantly lower in test group A than in test group B (visible absolute = 44.79 ± 15.77% vs. 65.12 ± 16.37%, p < 0.001; visible relative = 39.27 ± 14.33% vs. 59.24 ± 16.90%, p < 0.001; total = 65.17 ± 9.73% vs. 74.52 ± 13.55%, p = 0.007). Accounting for the growth rate with the placebo mouthwash on day 4, the above results imply that the cymenol mouthwash in the last four days of the trial reduced the growth rate of the area of visible plaque (absolute and relative) by 53% (test group A) and 29% (test group B), and of the area of total plaque by 48% (test group A) and 41% (test group B).ConclusionsThe 0.1% cymenol mouthwash has a short-term anti-plaque effect in situ, strongly conditioning the rate of plaque growth, even in clinical situations with high levels of dental plaque accumulation.
PB BMC
YR 2023
FD 2023-08-12
LK https://hdl.handle.net/10347/40979
UL https://hdl.handle.net/10347/40979
LA eng
NO Suárez-Rodríguez, B., Regueira-Iglesias, A., Blanco-Pintos, T. et al. Short-term anti-plaque effect of a cymenol mouthwash analysed using the DenTiUS Deep Plaque software: a randomised clinical trial. BMC Oral Health 23, 560 (2023). https://doi.org/10.1186/s12903-023-03256-9
NO Grant 2021-CE112 funded this research by Lacer, S.A. The funders were not involved in collecting and analysing the data or interpreting the results.
DS Minerva
RD 24 abr 2026