RT Journal Article
T1 Multifunctional Superparamagnetic Stiff Nanoreservoirs for Blood Brain Barrier Applications
A1 Vargas Osorio, Zulema
A1 Silva Candal, Andrés da
A1 Piñeiro Redondo, Yolanda
A1 Iglesias Rey, Ramón
A1 Sobrino Moreiras, Tomás
A1 Campos Pérez, Francisco
A1 Castillo Sánchez, José Antonio
A1 Rivas Rey, José
K1 Theranostic nanostructure
K1 MRI contrast
K1 Neurological diseases
AB Neurological diseases (Alzheimer’s disease, Parkinson’s disease, and stroke) are becominga major concern for health systems in developed countries due to the increment of ageing in thepopulation, and many resources are devoted to the development of new therapies and contrastagents for selective imaging. However, the strong isolation of the brain by the brain blood barrier(BBB) prevents not only the crossing of pathogens, but also a large set of beneficial drugs. Therefore,an alternative strategy is arising based on the anchoring to vascular endothelial cells of nanoplatformsworking as delivery reservoirs. In this work, novel injectable mesoporous nanorods, wrapped bya fluorescent magnetic nanoparticles envelope, are proposed as biocompatible reservoirs with anextremely high loading capacity, surface versatility, and optimal morphology for enhanced graftingto vessels during their diffusive flow. Wet chemistry techniques allow for the development ofmesoporous silica nanostructures with tailored properties, such as a fluorescent response suitablefor optical studies, superparamagnetic behavior for magnetic resonance imaging MRI contrast, andlarge range ordered porosity for controlled delivery. In this work, fluorescent magnetic mesoporousnanorods were physicochemical characterized and tested in preliminary biological in vitro andin vivo experiments, showing a transversal relaxivitiy of 324.68 mM−1s−1, intense fluorescence, largespecific surface area (300 m2 g−1), and biocompatibility for endothelial cells’ uptake up to 100 µg (ina 80% confluent 1.9 cm2culture well), with no liver and kidney disability. These magnetic fluorescentnanostructures allow for multimodal MRI/optical imaging, the allocation of therapeutic moieties,and targeting of tissues with specific damage.
PB MDPI
YR 2019
FD 2019
LK http://hdl.handle.net/10347/21349
UL http://hdl.handle.net/10347/21349
LA eng
NO Vargas-Osorio, Z.; Da Silva-Candal, A.; Piñeiro, Y.; Iglesias-Rey, R.; Sobrino, T.; Campos, F.; Castillo, J.; Rivas, J. Multifunctional Superparamagnetic Stiff Nanoreservoirs for Blood Brain Barrier Applications. Nanomaterials 2019, 9, 449
NO This work was supported by the European Commission under the PANA project, CallH2020-NMP-2015-two-stage, Grant 686009, and partially supported by the Consellería de Educación Programfor the Development of Strategic Grouping in Materials—AEMAT at the University of Santiago de Compostelaunder Grant No. ED431E2018/08, Xunta de Galicia, and Program for the Consolidation of Reasearch Units ofCompetitive Reference GRC2017, Grant N. ED431C 2017/22.
DS Minerva
RD 24 abr 2026