RT Dissertation/Thesis
T1 Determining the role of the zinc-finger protein ZMYM2 in pluripotency
A1 Souto Becerra, Yara
K1 Pluripotency
K1 differentiation
K1 eprogramming
K1 epigenetics
K1 Zmym2
AB Mutations of the zinc finger MYM-type containing 2 (ZMYM2) protein altercellular and tissue homeostasis, but its functional roles in pluripotency are largely unexplored. Here, I show thatZMYM2 is a key component of the core regulatory network that governs pluripotency. My data reveal that ZMYM2is a roadblock to efficient somatic cell reprogramming and is required to fine-tune the self-renewal of ESCs and theearly differentiation process. Mechanistically, I found that ZMYM2 and LSD1 associate for the transcriptional controlof pluripotency and differentiation genes. This study therefore establishes a novel transcriptional regulatory modededicated to reprogramming and pluripotency, and open new avenues for exploring the involvement of ZMYM2-LSD1 partnership in development and disease.
YR 2022
FD 2022
LK http://hdl.handle.net/10347/28763
UL http://hdl.handle.net/10347/28763
LA eng
DS Minerva
RD 24 abr 2026