RT Journal Article
T1 Marine toxins and the cytoskeleton: okadaic acid and dinophysistoxins
A1 Vale González, María del Carmen
A1 Botana López, Luis Miguel
K1 Actin
K1 Cytoskeleton
K1 Diarrheic shellfish poisoning
K1 Dinophysistoxins
K1 DSP
K1 Methyl okadaate
K1 Microtubules
K1 OA
K1 Okadaic acid
K1 Phycotoxin
AB Okadaic acid (OA) and its analogs, the dinophysistoxins, are potent inhibitors of protein phosphatases 1 and 2A. This action is well known to cause diarrhea and gastrointestinal symptons when the toxins reach the digestive tract by ingestion of mollusks. A less well-known effect of these group of toxins is their effect in the cytoskeleton. OA has been shown to stimulate cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization due to an alteration in the tyrosine-phosphorylated state of the focal adhesion kinases and paxillin. OA causes cell rounding and loss of barrier properties through mechanisms that probably involve disruption of filamentous actin (F-actin) and/or hyperphosphorylation and activation of kinases that stimulate tight junction disassembly. Neither methyl okadaate (a weak phosphatase inhibitor) nor OA modify the total amount of F-actin, but both toxins cause similar changes in the F-actin cytoskeleton, with strong retraction and rounding, and in many cases cell detachment. OA and dinophysistoxin-1 (35S-methylokadaic acid) cause rapid changes in the structural organization of intermediate filaments, followed by a loss of microtubules, solubilization of intermediate filament proteins, and disruption of desmosomes. The detailed pathways that coordinate all these effects are not yet known.
PB Wiley
YR 2008
FD 2008-09-25
LK https://hdl.handle.net/10347/46868
UL https://hdl.handle.net/10347/46868
LA eng
NO Vale C, Botana LM. Marine toxins and the cytoskeleton: okadaic acid and dinophysistoxins. FEBS J. 2008 Dec;275(24):6060-6. doi: 10.1111/j.1742-4658.2008.06711.x. Epub 2008 Oct 24. PMID: 19016863.
NO This is the accepted version of the following article: Vale C, Botana LM. Marine toxins and the cytoskeleton: okadaic acid and dinophysistoxins. FEBS J. 2008 Dec;275(24):6060-6, which has been published in final form at https://doi.org/10.1111/j.1742-4658.2008.06711.x
DS Minerva
RD 9 may 2026