RT Journal Article
T1 Effect of a Very-Low-Calorie Ketogenic Diet on Circulating Myokine Levels Compared with the Effect of Bariatric Surgery or a Low-Calorie Diet in Patients with Obesity
A1 Sajoux, Ignacio
A1 Lorenzo, Paula M.
A1 Gómez Arbeláez, Diego Eduardo
A1 Zulet, M. Angeles
A1 Abete, Itziar
A1 Castro, Ana I.
A1 Baltar, Javier
A1 Portillo, María P.
A1 Tinahones Madueño, Francisco José
A1 Martínez, José Alfredo
A1 Crujeiras Martínez, Ana Belén
A1 Casanueva Freijo, Felipe
K1 Bariatric surgery
K1 Body composition
K1 Fat free mass
K1 Ketogenic diet
K1 Obesity
K1 PnK method
K1 Protein diet
K1 Low-calorie diet
K1 Very low-energy diet
AB The preservation of muscle mass and muscle function after weight loss therapy is currently a considerable challenge in the fight against obesity. Muscle mass secretes proteins called myokines that have relevant functions in the regulation of metabolism and health. This study was aimed to evaluate whether a very low-calorie ketogenic (VLCK) diet may modulate myokine levels, in addition to changes in body composition, compared to a standard, balanced low-calorie (LC) diet or bariatric surgery in patients with obesity. Body composition, ketosis, insulin sensitivity and myokines were evaluated in 79 patients with overweight/obesity after a therapy to lose weight with a VLCK diet, a LC diet or bariatric surgery. The follow-up was 6 months. The weight loss therapies induced changes in myokine levels in association with changes in body composition and biochemical parameters. The effects on circulating myokine levels compared to those at baseline were stronger after the VLCK diet than LC diet or bariatric surgery. Differences reached statistical significance for IL-8, MMP2 and irisin. In conclusion, nutritional interventions or bariatric surgery to lose weight induces changes in circulating myokine levels, being this effect potentially most notable after following a VLCK diet
PB MDPI
YR 2019
FD 2019
LK http://hdl.handle.net/10347/23819
UL http://hdl.handle.net/10347/23819
LA eng
NO Sajoux, I.; Lorenzo, P.M.; Gomez-Arbelaez, D.; Zulet, M.A.; Abete, I.; Castro, A.I.; Baltar, J.; Portillo, M.P.; Tinahones, F.J.; Martinez, J.A.; Crujeiras, A.B.; Casanueva, F.F. Effect of a Very-Low-Calorie Ketogenic Diet on Circulating Myokine Levels Compared with the Effect of Bariatric Surgery or a Low-Calorie Diet in Patients with Obesity. Nutrients 2019, 11, 2368
NO This work was supported by the PronoKal Group® and grants from the Fondo de Investigacion Sanitaria, PI17/01287 research projects and CIBERobn (CB06/03/0003, CB12/03/30007, CB12/03/30002, CB06/03/0018) from the Instituto de Salud Carlos III (ISCIII)-Subdireccion General de Evaluacion y Fomento de la Investigación; Fondo Europeo de Desarrollo Regional (FEDER) and the Health Department of the Government of Navarra (48/2009), Spain and Linea Especial “Nutrition, Obesity and Health” (University of Navarra LE/97). Ana B Crujeiras is funded by a research contract “Miguel Servet” (CP17/00088) from the ISCIII, co-financed by the European Regional Development Fund (FEDER)
DS Minerva
RD 24 abr 2026