RT Journal Article
T1 Assessing Cocaine Use Patterns in the Brazilian Capital by Wastewater-Based Epidemiology
A1 Silva, Katyeny Manuela da
A1 Quintana Álvarez, José Benito
A1 González Mariño, Iria
A1 Rodil Rodríguez, María del Rosario
A1 Donatti Gallassi, Andrea
A1 Arantes, Luciano Chaves
A1 Sodré, Fernando Fabriz
K1 Wastewater-based epidemiology
K1 Cocaine
K1 Crack
K1 Brazil
K1 Cocaethylene
AB The levels of cocaine (COC) and its metabolites benzoylecgonine (BE) and cocaethylene (COE) in wastewater samples from Brasilia, Brazil, were determined using liquid chromatography coupled to hybrid quadrupole-time-of-flight mass spectrometry. The former metabolite was used to estimate cocaine consumption using a country-tuned correction factor that considers BE excretion rates for different routes of administration as well as the fraction of crack users in Brazil. A day-to-day analysis during a week indicates higher cocaine use in weekends with peaks on Sunday in both southern (7385 ± 121 mg day−1 1000 inhab−1) and northern (3566 ± 171 mg day−1 1000 inhab−1) areas of Brasilia. A significant high cocaine use was also observed in the Carnival Day of 2018 (6229 ± 219 mg day−1 1000 inhab−1). COE/BE ratios were used to assess COC and alcohol co-consumption since COE is produced during the co-consumption of both substances. Higher ratios were also observed during the weekend. However, higher ratios on Saturdays rather than Sundays may be explained by the decrease of BE excretion during the co-consumption with alcohol, which may lead to an underestimation of the cocaine use estimates on Saturdays, as well as by different patterns of co-consumption by powder and crack users, where the latter usually drink lower amounts of alcohol. Our data suggest that only 3% of cocaine was seized by the local Technical Police during the study
PB Taylor & Francis
SN 0306-7319
YR 2018
FD 2018-12-10
LK http://hdl.handle.net/10347/18087
UL http://hdl.handle.net/10347/18087
LA eng
NO da Silva, K., Quintana, J., González-Mariño, I., Rodil, R., Gallassi, A., Arantes, L., & Sodré, F. (2018). Assessing cocaine use patterns in the Brazilian Capital by wastewater-based epidemiology. International Journal Of Environmental Analytical Chemistry, 98(15), 1370-1387. doi: 10.1080/03067319.2018.1554743
NO This is the postprint (accepted manuscript) version of the article published by Taylor & Francis in the International Journal of Environmental Analytical Chemistry on December, 10th 2018. Available on-line: http://www.tandfonline.com//10.1080/03067319.2018.1554743
NO This work was supported by the Federal District Research Foundation under Grant [193.000.916/2015]; the Spanish Agencia Estatal de Investigación under Grant [CTM2017-84763-C3-2-R]; theGalician Council of Culture, Education and Universities under Grants [ED431C2017/36]; IGM postdoctoralcontract, Plan Galego I2C-Modalidade B, ED481D 2017/003; and FEDER/ERDF
DS Minerva
RD 23 abr 2026