RT Journal Article
T1 Brain Recovery after a Plane Crash: Treatment with Growth Hormone (GH) and Neurorehabilitation: A Case Report
A1 Devesa Múgica, Jesús
A1 Díaz Getino, Gustavo
A1 Rey, Pablo
A1 García Cancela, José
A1 Loures, Iria
A1 Nogueiras, Sonia
A1 Hurtado de Mendoza, Alba
A1 Salgado, Lucía
A1 González, Mónica
A1 Pablos, Tamara
A1 Devesa Peleteiro, Pablo
K1 GH
K1 Traumatic brain injury
K1 Neurorehabilitation
K1 Brain plasticity
K1 Adult neurogenesis
K1 Cognitive functions
K1 Spastic tetraplegia
AB The aim of this study is to describe the results obtained after growth hormone (GH) treatment and neurorehabilitation in a young man that suffered a very grave traumatic brain injury (TBI) after a plane crash. Methods: Fifteen months after the accident, the patient was treated with GH, 1 mg/day, at three-month intervals, followed by one-month resting, together with daily neurorehabilitation. Blood analysis at admission showed that no pituitary deficits existed. At admission, the patient presented: spastic tetraplegia, dysarthria, dysphagia, very severe cognitive deficits and joint deformities. Computerized tomography scanners (CT-Scans) revealed the practical loss of the right brain hemisphere and important injuries in the left one. Clinical and blood analysis assessments were performed every three months for three years. Feet surgery was needed because of irreducible equinovarus. Results: Clinical and kinesitherapy assessments revealed a prompt improvement in cognitive functions, dysarthria and dysphagia disappeared and three years later the patient was able to live a practically normal life, walking alone and coming back to his studies. No adverse effects were observed during and after GH administration. Conclusions: These results, together with previous results from our group, indicate that GH treatment is safe and effective for helping neurorehabilitation in TBI patients, once the acute phase is resolved, regardless of whether or not they have GH-deficiency (GHD)
PB MDPI
YR 2015
FD 2015
LK http://hdl.handle.net/10347/23014
UL http://hdl.handle.net/10347/23014
LA eng
NO Devesa, J., Díaz-Getino, G., Rey, P., García-Cancela, J., Loures, I., Nogueiras, S., Hurtado de Mendoza, A., et al. (2015). Brain Recovery after a Plane Crash: Treatment with Growth Hormone (GH) and Neurorehabilitation: A Case Report. International Journal of Molecular Sciences, 16(12), 30470–30482. MDPI AG. Retrieved from http://dx.doi.org/10.3390/ijms161226244
NO This study was supported by Foundation Foltra
DS Minerva
RD 24 abr 2026