RT Journal Article
T1 New sequence variants in HLA Class II/III region associated with susceptibility to knee osteoarthritis identified by genome-wide association study
A1 Nakajima, Masahiro
A1 Takahashi, Atsushi
A1 Kou, Ikuyo
A1 Rodríguez Fontenla, María Cristina
A1 Gómez-Reino Carnota, Juan Jesús
A1 Furuichi, Tatsuya
A1 Dai, Jin
A1 Sudo, Akihiro
A1 Uchida, Atsumasa
A1 Fukui, Naoshi
A1 Kubo, Michiaki
A1 Kamatani, Naoyuki
A1 Tsunoda, Tatsuhiko
A1 Malizos, Konstantinos N.
A1 Tsezou, Aspasia
A1 González Martínez-Pedrayo, Antonio
A1 Nakamura, Yusuke
A1 Ikegawa, Shiro
K1 Osteoarthritis
K1 Knee Osteoarthritis
K1 Genome-wide identification
K1 HLA Class II/III
AB Osteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have been reported, however. Through a genome-wide association study and a replication using a total of ∼4,800 Japanese subjects, we identified two single nucleotide polymorphisms (SNPs) (rs7775228 and rs10947262) associated with susceptibility to knee OA. The two SNPs were in a region containing HLA class II/III genes and their association reached genome-wide significance (combined P = 2.43×10−8 for rs7775228 and 6.73×10−8 for rs10947262). Our results suggest that immunologic mechanism is implicated in the etiology of OA
PB Plos
YR 2010
FD 2010
LK http://hdl.handle.net/10347/22836
UL http://hdl.handle.net/10347/22836
LA eng
NO Nakajima M, Takahashi A, Kou I, Rodriguez-Fontenla C, Gomez-Reino JJ, Furuichi T, et al. (2010) New Sequence Variants in HLA Class II/III Region Associated with Susceptibility to Knee Osteoarthritis Identified by Genome-Wide Association Study. PLoS ONE 5(3): e9723. https://doi.org/10.1371/journal.pone.0009723
NO The Japanese study is supported by the Leading Project for Personalized Medicine in the Ministry of Education, Culture, Sports, Science and Technology. The European study is supported by Instituto de Salud Carlos III from the Spanish Health Ministry with participation of FEDER (Fondo Europeo para el Desarrollo Regional), the Foundation Mutua Madrile (Madrid)
DS Minerva
RD 4 may 2026