RT Journal Article
T1 Determination of N-Nitrosamines by Gas Chromatography Coupled to Quadrupole–Time-of-Flight Mass Spectrometry in Water Samples
A1 Sieira Nóvoa, Benigno José
A1 Carpinteiro Botana, María Inmaculada
A1 Rodil Rodríguez, María del Rosario
A1 Quintana Álvarez, José Benito
A1 Cela Torrijos, Rafael
K1 Gas chromatography–mass spectrometry (GC-MS)
K1 High-resolution mass spectrometry (HRMS)
K1 N-nitrosamines
K1 Water samples
K1 Positive chemical ionization (PCI)
AB An analytical method based on high-resolution quadrupole–time-of-flight (QToF) mass spectrometry has been developed as an alternative to the classical method, using a low-resolution ion trap (IT) analyzer to reduce interferences in N-nitrosamines determination. Extraction of the targeted compounds was performed by solid-phase extraction (SPE) following the United States Environmental Protection Agency (USEPA) -521 method. First, both electron impact (EI) and positive chemical ionization (PCI) using methane as ionization gas were compared, along with IT and QToF detection. Then, parameters such as limits of detection (LOD) and quantification (LOQ), linearity, and repeatability were assessed. The results showed that the QToF mass analyzer combined with PCI was the best system for the determination of the N-nitrosamines, with instrumental LOD and LOQ in the ranges of 0.2–4 and 0.6–11 ng mL−1, respectively, which translated into method LOD and LOQ in the ranges of 0.2–1.3 and 0.6–3.9 ng L−1, respectively. The analysis of real samples showed the presence of 6 of the N-nitrosamines in influent, effluent, and tap water. N-nitrosodimethylamine (NDMA) was quantified in all the analyzed samples at concentrations between 1 and 27 ng L−1. Moreover, four additional nitrosamines were found in tap and wastewater samples
PB MDPI
SN 2297-8739
YR 2020
FD 2020-01-03
LK http://hdl.handle.net/10347/20585
UL http://hdl.handle.net/10347/20585
LA eng
NO Sieira, B.J.; Carpinteiro, I.; Rodil, R.; Quintana, J.B.; Cela, R. Determination of N-Nitrosamines by Gas Chromatography Coupled to Quadrupole–Time-of-Flight Mass Spectrometry in Water Samples. Separations 2020, 7(1), 3. https://doi.org/10.3390/separations7010003
NO This research was funded by Xunta de Galicia (references EM2014/004 and ED431C2017/36), Spanish Agencia Estatal de Investigación (reference CTM2017-84763-C3-R-2), and European Regional Development Fund (FEDER/ERDF) funds. I.C. acknowledges her postdoctoral formation grant from Xunta de Galicia government
DS Minerva
RD 22 abr 2026