RT Journal Article
T1 Improving the solubility of the antichagasic drug benznidazole through formation of inclusion complexes with cyclodextrins
A1 Sobrinho, José Lamartine Soares
A1 Soares, Mônica Felts de La Roca
A1 Torres Labandeira, Santiago
A1 Alves, Lariza Darlene Santos
A1 Neto, Pedro José Rolim
K1 Benznidazole
K1 Chagas disease
K1 Inclusion complex and dissolution
AB This study describes unpublished research on improving the solubility of benznidazole by the formation of an inclusion complex. The cyclodextrins selected were αCD, βCD, γCD, HPβCD, RMβCD and SBβCD. All complexes were obtained in solution, presenting 1:1 stoichiometry according to the phase solubility diagram. The highest association constants were obtained with RMβCD and SBβCD, being selected for attainment of solid state complexes. These were characterized using XRD, SEM and dissolution test. The data obtained suggest the formation of complexes and indicate that these may provide a promising alternative way of developing solid doses of drug with suitable biopharmaceutical properties.
PB Sociedade Brasileira de Química
SN 0100-4042
YR 2011
FD 2011
LK http://hdl.handle.net/10347/21996
UL http://hdl.handle.net/10347/21996
LA eng
NO Sobrinho, José Lamartine Soares, Soares, Mônica Felts de La Roca, Labandeira, Juan Jose Torres, Alves, Lariza Darlene Santos, & Rolim Neto, Pedro José. (2011). Improving the solubility of the antichagasic drug benznidazole through formation of inclusion complexes with cyclodextrins. "Química Nova", 34(9), 1534-1538
DS Minerva
RD 23 abr 2026