RT Journal Article
T1 Click Chemistry for Drug Delivery Nanosystems
A1 Lallana, Enrique
A1 Sousa Hervés, Ana
A1 Fernández Trillo, Francisco
K1 Bioconjugation
K1 Click chemistry
K1 CuAAC
K1 Drug delivery
K1 Nanostructure
AB The purpose of this Expert Review is to discuss the impact of click chemistry in nanosized drug delivery systems. Since the introduction of the click concept by Sharpless and coworkers in 2001, numerous examples of click reactions have been reported for the preparation and functionalization of polymeric micelles and nanoparticles, liposomes and polymersomes, capsules, microspheres, metal and silica nanoparticles, carbon nanotubes and fullerenes, or bionanoparticles. Among these click processes, Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) has attracted most attention based on its high orthogonality, reliability, and experimental simplicity for non-specialists. A renewed interest in the use of efficient classical transformations has been also observed (e.g., thiol-ene coupling, Michael addition, Diels-Alder). Special emphasis is also devoted to critically discuss the click concept, as well as practical aspects of application of CuAAC to ensure efficient and harmless bioconjugation
PB Springer
SN 0724-8741
YR 2012
FD 2012
LK http://hdl.handle.net/10347/16965
UL http://hdl.handle.net/10347/16965
LA eng
NO Lallana, E., Sousa-Herves, A., Fernandez-Trillo, F. et al. Pharm Res (2012) 29: 1. https://doi.org/10.1007/s11095-011-0568-5
NO This is a post-peer-review, pre-copyedit version of an article published in Pharmaceutical Research. The final authenticated version is available online at: https://doi.org/10.1007/s11095-011-0568-5
NO This work was financially supported by the Spanish Ministry of Science and Innovation (CTQ2009-10963 and CTQ2009-14146-C02-02) and the Xunta de Galicia (10CSA209021PR)
DS Minerva
RD 23 abr 2026