RT Journal Article
T1 Ruthenium-Catalyzed Tandem Carbene/Alkyne Metathesis/N-H insertion. Synthesis of Benzofused Six-Membered Azaheterocycles
A1 Padín Santos, Damián
A1 Varela Carrete, Jesús Ángel
A1 Saá Rodríguez, Carlos
K1 Carbenes
K1 Carbene/Alkyne metathesis
K1 N-H insertion
K1 Tandem reactions
K1 Ruthenium
AB Cp*RuCl-based catalyst enables the expedient access to a variety of benzofused six- membered azaheterocycles from unprotected o-alkynylanilines and trimethylsilyldiazomethane through an unprecedent tandem carbene/alkyne metathesis/N-H insertion reaction. The transformation takes place under mild reaction conditions (room temperature, < 15 min) and with excellent functional group tolerance. The synthetic utility of the final products and a mechanistic rationale are also discussed.
PB American Chemical Society
SN 1523-7060
YR 2020
FD 2020
LK http://hdl.handle.net/10347/23357
UL http://hdl.handle.net/10347/23357
LA eng
NO Padín, D., Varela, J. A., Saá, C. (2020). Ruthenium-Catalyzed Tandem Carbene/Alkyne Metathesis/N-H insertion. Synthesis of Benzofused Six-Membered Azaheterocycles. Org. Lett., 22, 7, 2621-2625
NO NOTICE: This is the peer reviewed version of the following article: Padín, D., Varela, J. A., Saá, C. (2020). Ruthenium-Catalyzed Tandem Carbene/Alkyne Metathesis/N-H insertion. Synthesis of Benzofused Six-Membered Azaheterocycles. Org. Lett., 22, 7, 2621-2625. [doi: 10.1021/acs.orglett.0c00596]. This article may be used for non-commercial purposes in accordance with American Chemical Society Terms and Conditions for self-archiving
NO This work has received financial support from MINECO (project CTQ2017-87939R and ORFEO-CINQA network RED2018-102387-T), the Xunta de Galicia (project ED431C 2018/04 and Centro singular de investigación de Galicia accreditation 2019-2022, ED431G 2019/03) and the European Union (European Regional Development Fund – ERDF). D.P. thanks MEC for a predoctoral FPU fellowship (FPU15/02132)
DS Minerva
RD 24 abr 2026