RT Journal Article T1 Corona VRus Coaster: the virtual reality roller coaster of the proteins of SARS‑CoV‑2 A1 Seco González, Alejandro A1 Porto Vence, César A1 Piñeiro Guillén, Ángel A1 García Fandiño, Rebeca K1 Virtual reality K1 SARS-CoV-2 K1 Protein visualization K1 Molecular structures K1 Immersive technology AB The COVID-19 pandemic, caused by SARS-CoV-2, has driven significant research into the virus’ structural components to elucidate its infection mechanisms and advance therapeutic strategies. However, the intricate architecture of viral proteins presents challenges for researchers and students in structural biology. To address this, we developed Corona VRus Coaster, a virtual reality (VR) application designed to facilitate molecular visualization. This tool enables immersive exploration of over 2000 viral proteins, including key structures such as the spike protein, nucleocapsid protein, main protease, and RNA-dependent RNA polymerase. Users can “ride” along the molecular backbones of these proteins, offering a distinctive way to explore their three-dimensional organization. Hand-tracking technology provides an intuitive interface for real-time interaction, while multiple visualization and navigation modes enhance the exploration experience. This application offers a novel and engaging approach to structural biology, supporting both research and education by making molecular structures more accessible and interactive. Corona VRus Coaster is available for download at http://mduse.com/coronavruscoaster. PB Springer Nature SN 1610-2940 YR 2025 FD 2025-08-06 LK https://hdl.handle.net/10347/43053 UL https://hdl.handle.net/10347/43053 LA eng NO Seco-González, A., Porto, C., Piñeiro, Á. et al. Corona VRus Coaster: the virtual reality roller coaster of the proteins of SARS-CoV-2. J Mol Model 31, 233 (2025). https://doi.org/10.1007/s00894-025-06455-z NO Spanish Agencia Estatal de Investigación (AEI) (PID2019- 111327 GB-I00, PDC2022-133402-I00, PID2022-141534OB-I00, and CNS2023-144353) NO European Union through the European Regional Development Fund (ERDF) DS Minerva RD 2 may 2026