RT Journal Article
T1 Determination of the toxicity equivalency factors for ciguatoxins using human sodium channels
A1 Raposo García, Sandra
A1 Louzao Ojeda, María del Carmen
A1 Fuwa, Haruhiko
A1 Sasaki, Makoto
A1 Vale González, María del Carmen
A1 Botana López, Luis Miguel
K1 Ciguatoxin
K1 Gambierol
K1 Gambierone
K1 44-Methyl gambierone
K1 Sodium channel
AB Ciguatoxins (CTXs) which are produced by dinoflagellates of the genus Gambierdiscus and Fukuyoa and share a ladder-shaped polyether structure, are causative compounds of one of the most frequent foodborne illness disease known as ciguatera fish poisoning (CFP). CFP was initially found in tropical and subtropical areas but nowadays the dinoflagellates producers of ciguatoxins had spread to European coasts. Therefore, this raises the need of establishing toxicity equivalency factors for the different compounds that can contribute to ciguatera fish poisoning, since biological methods have been replaced by analytical techniques. Thus, in this work, the effects of six compounds causative of ciguatera, on their main target, the human voltage-gated sodium channels have been analyzed for the first time. The results presented here led to the conclusion that the order of potency was CTX1B, CTX3B, CTX4A, gambierol, gambierone and MTX3. Furthermore, the data indicate that the activation voltage of sodium channels is more sensitive to detect ciguatoxins than their effect on the peak sodium current amplitude
PB Elsevier
YR 2022
FD 2022
LK http://hdl.handle.net/10347/27595
UL http://hdl.handle.net/10347/27595
LA eng
NO Food and Chemical Toxicology 160 (2022) 112812
NO The research leading to these results has received funding from the following FEDER cofunded-grants. From Conselleria de Cultura, Educacion e Ordenación Universitaria, Xunta de Galicia, GRC (ED431C 2021/01). From Ministerio de Ciencia e Innovación IISCIII/PI19/001248, PID 2020-11262RB-C21. From European Union Interreg AlertoxNet EAPA-317-2016, Interreg Agritox EAPA-998-2018, and H2020 778069-EMERTOX
DS Minerva
RD 24 abr 2026