RT Journal Article
T1 Bimodal effect of interferon-β on astrocyte proliferation and survival: Importance of nuclear factor-κB
A1 Barca Mayo, Olga
A1 Devesa Peleteiro, Pablo
A1 Seoane, Marcos
A1 Señarís Rodríguez, Rosa María
A1 Arce Vázquez, Víctor Manuel
K1 Interferon Beta
K1 Nuclear factor-kappa beta
K1 Tumor necrosis factor
K1 Astrocyte proliferation
K1 Astrocyte survival
K1 Multiple sclerosis
AB Accumulating evidence indicates that interferon-β (IFN-β) can modify the complex immunopathogenic scenario causing clinical relapse activity and disease progression in MS. However, the beneficial effects of IFN-β in MS patients may also depend on non-immune mechanisms, including the modulation of astrocyte function. In the present report, we have shown that, depending on the dose, IFN-β treatment can either promote astrocyte proliferation and survival, or result astrocyte death. These actions depend, at least in part, on the regulation of nuclear factor-kappa B (NF-κB), an inducible transcription factor present in neurons and glia. This bimodal effect of IFN-β adds a new layer of complexity in the actions of IFN-β within the CNS.
PB Elsevier
SN 0165-5728
YR 2010
FD 2010-05-18
LK https://hdl.handle.net/10347/38852
UL https://hdl.handle.net/10347/38852
LA eng
NO Barca-Mayo O, Devesa-Peleteiro P, Seoane M, Señarís RM, Arce VM. Bimodal effect of interferon-β on astrocyte proliferation and survival: Importance of nuclear factor-κB."Journal of Neuroimmunology", 2010; 226(1-2): 73-80.
NO Fondo de Investigaciones Sanitarias (FIS 99/1188 and FIS 01/1007) and Xunta de Galicia (PGIDIT05BTF20801PR).
DS Minerva
RD 26 abr 2026