RT Journal Article
T1 Multifunctional polymeric guanidine and hydantoin halamines with broad biocidal activity
A1 Bromberg, Lev
A1 Magariños Ferro, Beatriz
A1 Torres, Beatriz S.
A1 Santos Rodríguez, Ysabel
A1 Concheiro Nine, Ángel Joaquín
A1 Hatton, T. Alan
A1 Álvarez Lorenzo, Carmen
K1 Halogenated polyamines
K1 Coronavirus inactivation, multidrug resistant  bacteria
K1 Antiviral
K1 Antifungal polymers
AB Prolonged and excessive use of biocides during the coronavirus disease era calls for incorporating new antiviral polymers that enhance the surface design and functionality for existing and potential future pandemics. Herein, we investigated previously unexplored polyamines with nucleophilic biguanide, guanidine, and hydantoin groups that all can be halogenated leading to high contents of oxidizing halogen that enables enhancement of the biocidal activity. Primary amino groups can be used to attach poly(N-vinylguanidine) (PVG) and poly(allylamine-co-4-aminopyridine-co-5-(4-hydroxybenzylidene)hydantoin) (PAH) as well as a broad-spectrum commercial biocide poly(hexamethylene biguanide) (PHMB) onto a solid support. Halogenation of polymer suspensions was conducted through in situ generation of excess hypobromous acid (HBrO) from bromine and sodium hydroxide or by sodium hypochlorite in aqueous solutions, resulting in N-halamines with high contents of active > N-Br or > N-Cl groups. The virucidal activity of the polymers against human respiratory coronavirus HCoV-229E increased dramatically with their halogenation. Brominated PHMB-Br showed activation activity value > 5 even at 1 mg/L, and complete virus inhibition was observed with either PHMB-Br or PAH-Br at 10 mg/mL. Brominated PVG-Br and PAH-Br possessed fungicidal activity against C. albicans, while PHMB was fungistatic. PHMB, PHMB-Br and PAH polymers demonstrated excellent bactericidal activity against the methicillin-resistant S. aureus and vancomycin-resistant E. faecium. Brominated polymers (PHMB-Br, PVG-Br, PAH-Br) were not toxic to the HeLa monolayers, indicating acceptable biocompatibility to cultured human cells. With these features, the N-halamine polymers of the present study are a worthwhile addition to the arsenal of biocides and are promising candidates for development of non-leaching coatings
PB Elsevier
SN 0378-5173
YR 2024
FD 2024
LK http://hdl.handle.net/10347/33768
UL http://hdl.handle.net/10347/33768
LA eng
NO International Journal of Pharmaceutics, Volume 651, 2024, 123779
NO The work was supported by MCIN/AEI/10.13039/501100011033 [PID 2020-113881RB-I00], Spain, Xunta de Galicia [ED431C 2020/17], and FEDER
DS Minerva
RD 28 abr 2026