RT Journal Article
T1 Iridium(I)-Catalyzed Intramolecular Hydrocarbonation of Alkenes: Efficient Access to Cyclic Systems Bearing Quaternary Stereocenters
A1 Fernández Fernández, David
A1 Gulías Costa, Moisés
A1 Mascareñas Cid, José Luis
A1 López García, Fernando
K1 C−H activation
K1 Asymmetric catalysis
K1 Hydroalkenylation
K1 Hydroarylation
K1 Iridium
AB A catalytic, versatile and atom-economical C−H functionalization process that provides a wide variety of cyclic systems featuring methyl-substituted quaternary stereocenters is described. The method relies on the use of a cationic IrI–bisphosphine catalyst, which promotes a carboxamide-assisted activation of an olefinic C(sp2)−H bond followed by exo-cyclization to a tethered 1,1-disubstituted alkene. The extension of the method to aromatic and heteroaromatic C−H bonds, as well as developments on an enantioselective variant, are also described
PB Wiley
YR 2017
FD 2017-07-12
LK http://hdl.handle.net/10347/15752
UL http://hdl.handle.net/10347/15752
LA eng
NO David Fernández, Moisés Gulías, José L. Mascareñas, Fernando López (2017), Iridium (I)-Catalyzed Intramolecular Hydrocarbonation of Alkenes: Efficient Access to Cyclic Systems Bearing Quaternary Stereocenters, Angew. Chem. Int. Ed., 56, 9541-9545 [doi: 10.1002/anie.201705105]
NO This is the peer reviewed version of the following article: David Fernández, Moisés Gulías, José L.Mascareñas, Fernando López (2017), Iridium (I)-Catalyzed Intramolecular Hydrocarbonation of Alkenes:Efficient Access to Cyclic Systems Bearing Quaternary Stereocenters, Angew. Chem. Int. Ed., 56, 9541-9545[doi: 10.1002/anie.201705105]. This article may be used for non-commercial purposes in accordance with WileyTerms and Conditions for self-archiving
NO This work has received financial support from the spanish MINECO grants (SAF2016-76689-R, CTQ2016-77047-P), Xunta de Galicia (GRC2013-041, 2015-CP082 and Centro Singular de Investigación de Galicia accreditation 2016–2019 ED431G/09), the European Union (European Regional Development Fund – ERDF) and ERC (Adv. Grant No. 340055). D.F.F. thanks the MINECO for a fellowship. The Orfeo-Cinqa network CTQ2014-51912-REDC is kindly acknowledged
DS Minerva
RD 30 abr 2026